Department of Pretreatment and Finishing of Cellulosic based Textiles, Textile Industries Research Division, National Research Centre, Scopus affiliation ID 60014618, 33 EL Buhouth St., Dokki, Giza 12622, Egypt.
Chemistry Department, Faculty of Science, Helwan University, Ain-Helwan, Cairo 11795, Egypt.
Int J Biol Macromol. 2021 Feb 15;170:688-700. doi: 10.1016/j.ijbiomac.2020.12.151. Epub 2020 Dec 29.
Requirement for medication from pathogenic human viruses and cancer diseases are urgently considered, while, numerous reports were focused on investigating easily manufactured and excellently effective therapeutic reagents. Herein, CQDs were prepared with size of 2.1 nm from both of carrageenan and pullulan. CQDs nucleated from pullulan showed higher anti-proliferative effects against cancer cells, while, treatment with 100 μg/mL of CQDs colloids originated from pullulan and carrageenan separately resulted in diminishing of cancer cell viability percent to be 42.1 & 58.7%, respectively. Plaque reduction assay was also affirmed that, 2.5 μg/L of both of pullulan and carrageenan based CQDs exhibited viral inhibition with percent of 44.3& 59.5%, respectively. As a conclusion, pullulan showed seniority over carrageenan in nucleation of CQDs with higher anticancer activities. While, estimation of antiviral performance of the prepared CQDs confirmed the priority of carrageenan compared to pullulan in preparation of CQDs as antiviral laborer.
urgently considered. 同时,大量的报告集中于研究易于制造且具有卓越疗效的治疗试剂。在此,我们使用卡拉胶和普鲁兰多糖分别制备了粒径为 2.1nm 的 CQDs。从普鲁兰多糖中形成的 CQDs 对癌细胞表现出更高的抗增殖作用,而用 100μg/ml 的 CQDs 胶体处理分别导致源自普鲁兰多糖和卡拉胶的癌细胞活力降低到 42.1%和 58.7%。噬斑减少试验也证实,2.5μg/L 的普鲁兰多糖和卡拉胶基 CQDs 分别表现出 44.3%和 59.5%的病毒抑制率。总之,普鲁兰多糖在 CQDs 的成核中表现出比卡拉胶更高的优越性,具有更高的抗癌活性。而对所制备的 CQDs 的抗病毒性能的评估证实,在制备抗病毒 CQDs 方面,卡拉胶优先于普鲁兰多糖。