Almahri Albandary, Al-Bonayan Ameena M, Attar Roba M S, Karkashan Alaa, Abbas Basma, Al-Qahtani Salhah D, El-Metwaly Nashwa M
Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Department of Chemistry, Faculty of Applied Sciences, Umm Al-Qura University, Makkah 21421, Saudi Arabia.
ACS Omega. 2023 May 8;8(19):16956-16965. doi: 10.1021/acsomega.3c00873. eCollection 2023 May 16.
β-Cyclodextrin (CD) is currently exploited for the implantation of lipophobic polymer dots (PDs) for antimicrobial and anticancer laborers. Moreover, the PDs were investigated to act as a chemo-sensor for metal detection. The data revealed that under basic conditions, photoluminescent PDs (5.1 nm) were successively clustered with a controllable size at 190 °C, whereas under acidic conditions, smaller-sized non-photoluminescent carbon nanoparticles (2.9 nm) were obtained. The fluorescence intensity of synthesized PDs under basic conditions was affected by pH, and such an intensity was significantly higher compared to that prepared under acidic conditions. The PDs were exploited as florescent detectors in estimation of Ag ions in aquatic streams. Treatment of Ag ion colloids with PDs resulted in fluorescence quenching attributing to the production of AgNPs that approved by spectral studies. The cell viability percent was estimated for , and after incubation with PDs implanted under basic conditions for 24 h. The cell mortality percent was estimated for breast cancer (MCF-7) after incubation with different concentrations of PDs that were implanted under acidic versus basic conditions to show that treatment of the tested cells with 1000 μg/mL PDs prepared under basic (IC50 232.5 μg/mL) and acidic (IC 88.6 μg/mL) conditions resulted in cell mortality percentages of 70 and 90%, respectively.
β-环糊精(CD)目前被用于植入疏脂性聚合物点(PDs),用于抗菌和抗癌研究。此外,还研究了PDs作为金属检测的化学传感器的作用。数据显示,在碱性条件下,光致发光的PDs(5.1纳米)在190℃下以可控尺寸连续聚集,而在酸性条件下,获得了较小尺寸的非光致发光碳纳米颗粒(2.9纳米)。碱性条件下合成的PDs的荧光强度受pH值影响,且该强度明显高于酸性条件下制备的PDs。PDs被用作荧光探测器来估计水体中的银离子。用PDs处理银离子胶体导致荧光猝灭,这归因于光谱研究证实的银纳米颗粒的产生。在与碱性条件下植入的PDs孵育24小时后,估计了、和的细胞活力百分比。在用酸性和碱性条件下植入的不同浓度的PDs孵育后,估计了乳腺癌(MCF-7)的细胞死亡率百分比,结果表明,用碱性(IC50 232.5微克/毫升)和酸性(IC 88.6微克/毫升)条件下制备的1000微克/毫升PDs处理受试细胞,细胞死亡率分别为70%和90%。