Department of Chemistry, Isfahan University of Technology, Isfahan, I.R., 84156-83111, Iran.
Mikrochim Acta. 2021 Jan 2;188(1):1. doi: 10.1007/s00604-020-04655-3.
Polymelamine formaldehyde/graphene oxide (PMF/GO) nanocomposite was used, for the first time, to study the ultrasensitive and selective electrochemical detection of oxycodone (OXC). The successful characterization of PMF/GO was verified based on scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS), and Raman spectroscopy. The modified GCE (PMF/GO-GCE) proved its electrocatalytic effect on OXC determination according to cyclic, linear sweep, and differential pulse voltammetry (CV, LSV, and DPV) and electrochemical impedance spectroscopy (EIS) studies. The developed sensor under optimal conditions offered a linear relationship in a limited range of 0.01 to 45 μmol L with the limit of detection (LOD) of 2.0 nmol L. The proposed PMF/GO-GCE sensor was effectively employed for the OXC detection in human urine and serum samples. Graphical abstract.
首次使用三聚氰胺甲醛/氧化石墨烯（PMF/GO）纳米复合材料研究了羟考酮（OXC）的超灵敏和选择性电化学检测。通过扫描电子显微镜（SEM）、透射电子显微镜（TEM）、傅里叶变换红外（FT-IR）、X 射线衍射（XRD）、能谱（EDS）和拉曼光谱对 PMF/GO 的成功表征进行了验证。根据循环伏安法（CV）、线性扫描伏安法（LSV）和差分脉冲伏安法（DPV）以及电化学阻抗谱（EIS）研究，修饰后的 GCE（PMF/GO-GCE）证明了其对 OXC 测定的电催化作用。在最佳条件下，开发的传感器在 0.01 至 45 μmol·L 的有限范围内呈现线性关系，检测限（LOD）为 2.0 nmol·L。该方法已成功应用于人尿液和血清样品中 OXC 的检测。
