从一种源自红树林的真菌枝孢菌属JJM22中分离出的两种新的次生代谢产物。
Two new secondary metabolites from a mangrove-derived fungus Cladosporium sp. JJM22.
作者信息
Wu Jia-Ting, Zheng Cai-Juan, Zhang Bin, Zhou Xue-Ming, Zhou Qi, Chen Guang-Ying, Zeng Zhuo-Er, Xie Jin-Long, Han Chang-Ri, Lyu Ji-Xing
机构信息
a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education , College of Chemistry and Chemical Engineering, Hainan Normal University , Haikou , P. R. China.
b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province , School of Chemical and Material Engineering, Hainan Institute of Science and Technology , Haikou , P. R. China.
出版信息
Nat Prod Res. 2019 Jan;33(1):34-40. doi: 10.1080/14786419.2018.1431634. Epub 2018 Feb 1.
Two new compounds (1 and 2), together with six known compounds (3-8), were obtained from the Cladosporium sp. JJM22, an endophytic fungus isolated from the stem bark of the mangrove plant Ceriops tagal collected in South China Sea. Their structures were elucidated on the basis of detailed spectroscopic analysis. The absolute configurations of 1 and 2 were confirmed by the comparison of optical rotation and the CD data with those of known compounds. The inhibitory activities of the isolated compounds against six terrestrial pathogenic bacteria and human cervical carcinoma Hela cell line were evaluated. Compound 3 exhibited a broad spectrum of antibacterial activities.
从中国南海采集的红树植物角果木茎皮中分离得到的内生真菌枝孢菌属JJM22中，获得了两种新化合物（1和2）以及六种已知化合物（3 - 8）。通过详细的光谱分析阐明了它们的结构。通过将1和2的旋光度和圆二色数据与已知化合物的进行比较，确定了它们的绝对构型。评估了分离出的化合物对六种陆生致病细菌和人宫颈癌Hela细胞系的抑制活性。化合物3表现出广谱抗菌活性。
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