Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, People's Republic of China.
Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Hainan Normal University, Haikou, 571158, People's Republic of China.
J Antibiot (Tokyo). 2019 Oct;72(10):779-782. doi: 10.1038/s41429-019-0206-8. Epub 2019 Jul 2.
One new pentenoic acid derivative, named 1,1'-dioxine-2,2'-dipropionic acid (1) and a new natural product, named 2-methylacetate-3,5,6-trimethylpyrazine (2), along with six known compounds (3-8), were obtained from the Cladosporium sp. JS1-2, an endophytic fungus isolated from the mangrove Ceriops tagal collected in South China Sea. Their structures were elucidated by detailed analysis of comprehensive spectroscopic data, and the structure of 1 was further determined by X-ray diffraction analyses. C NMR chemical shifts of structure 2 was further determined by GIAO based C NMR chemical shifts calculations. Compounds 1-4 and 6 showed growth inhibition activities against newly hatched larvae of Helicoverpa armigera Hubner with the IC values ranging from 100 to 150 μg ml. Compounds 1, 2, 4, 6 and 7 showed moderate antibacterial activities against Staphylococcus aureus with the MIC values of 25.0, 12.5, 6.25, 1.25, and 6.25 μg ml, respectively.
从南海采集的红树植物杯萼海桑内生真菌 Cladosporium sp. JS1-2 中分离得到一个新的戊烯酸衍生物，命名为 1,1'-二氧杂环乙烷-2,2'-二丙酸（1）和一个新的天然产物，命名为 2-甲基乙酸酯-3,5,6-三甲基吡嗪（2），以及六个已知化合物（3-8）。通过综合光谱数据分析详细解析了它们的结构，通过 X 射线衍射分析进一步确定了 1 的结构。通过基于 GIAO 的 13C NMR 化学位移计算进一步确定了结构 2 的 13C NMR 化学位移。化合物 1-4 和 6 对新孵化的棉铃虫幼虫表现出生长抑制活性，IC50 值范围为 100-150μg/ml。化合物 1、2、4、6 和 7 对金黄色葡萄球菌表现出中等的抗菌活性，MIC 值分别为 25.0、12.5、6.25、1.25 和 6.25μg/ml。
