Department of Clinical Nutrition, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.
Department of Clinical Nutrition, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, China.
J Affect Disord. 2021 Mar 1;282:41-45. doi: 10.1016/j.jad.2020.12.098. Epub 2020 Dec 28.
The data for effect of dietary specific carotenoids on depression are limited and controversial. Thus, this study aimed to examine the relationship between dietary carotenoids intakes and the prevalence of depressive symptoms.
In the 2015-2016 United States National Health and Nutrition Examination Survey, 4,105 adults with complete data of dietary intake and assessment of depressive symptoms are enrolled. Dietary intake was assessed through two 24-h dietary recall interviews. Depression symptoms were assessed using the nine-item Patient Health Questionnaire. We used logistic regression to assess the relationship between diet carotenoids intake and the prevalence of depressive symptoms, adjusting for the main potential confounders. In addition, daily dietary carotenoids intake was adjusted for daily total energy intake based on the nutrient density model.
We found a significant inverse association between dietary beta-cryptoxanthin intake and depressive symptoms, with lowest prevalence in the third tertile (OR: 0.65, 95% CI: 0.47-0.90, p for trend < 0.001). Dose-response analyses revealed that the prevalence of depressive symptoms decreased with increasing intakes of beta-cryptoxanthin when reached the point above 110 ug/1000 Kcal. No such association was found for alpha-carotene, beta-carotene, lycopene, and lutein/zeaxanthin.
Increase the intake of beta-cryptoxathin-rich foods might protect from depressive symptoms. Further prospective studies are requested before dietary recommendation.
关于饮食中特定类胡萝卜素对抑郁症影响的数据有限且存在争议。因此，本研究旨在探究饮食类胡萝卜素摄入量与抑郁症状患病率之间的关系。
在 2015-2016 年美国国家健康和营养调查中，纳入了 4105 名饮食摄入和抑郁症状评估完整数据的成年人。通过两次 24 小时饮食回顾访谈评估饮食摄入。使用 9 项患者健康问卷评估抑郁症状。我们使用逻辑回归来评估饮食类胡萝卜素摄入量与抑郁症状患病率之间的关系，同时调整了主要潜在混杂因素。此外，基于营养素密度模型，根据每日总能量摄入量对每日饮食类胡萝卜素摄入量进行了调整。
我们发现饮食中β-隐黄质摄入量与抑郁症状之间存在显著负相关，第三 tertile（OR：0.65，95%CI：0.47-0.90，p 趋势<0.001）的患病率最低。剂量反应分析表明，当β-隐黄质摄入量超过 110ug/1000Kcal 时，抑郁症状的患病率随着摄入量的增加而降低。对于α-胡萝卜素、β-胡萝卜素、番茄红素和叶黄素/玉米黄质，未发现这种关联。
增加富含β-隐黄质的食物摄入可能有助于预防抑郁症状。在提出饮食建议之前，需要进一步进行前瞻性研究。
