Laboratory Medicine Unit, Ospedale dell'Angelo, Mestre, Italy.
Laboratory Medicine Unit, Ospedale dell'Angelo, Mestre, Italy.
Diagn Microbiol Infect Dis. 2021 Apr;99(4):115297. doi: 10.1016/j.diagmicrobio.2020.115297. Epub 2020 Dec 24.
The persistence of circulating antibodies to SARS-CoV-2 infection is not yet well known. We compare the results of 2 automated systems for the determination of IgG against SARS CoV-2 and assess the time-course of the IgG response.
IgG were measured in 103 specimens of 55 patients with COVID-19 (time from the symptoms' onset: 3-187 days) using the automated tests "Abbott SARS-COV-2 IgG" and "MAGLUMI 2019-nCoV IgG".
The 2 methods had a concordance of 90.3%, but the quantitative correlation, although significant, showed dispersed results. All the specimens resulted positive after 17 days. However, the median concentrations of IgG rapidly increased up to 20 days and decreased for Maglumi IgG while Abbott IgG showed a constant trend up to 85 days, and then slowly declined.
The titer of IgG against SARS-CoV-2 may significantly and rapidly decrease, but with a very different time-course depending on the method used for the determination.
目前尚不清楚 SARS-CoV-2 感染后循环抗体的持续时间。我们比较了两种用于检测 SARS-CoV-2 抗体 IgG 的自动化系统的结果，并评估了 IgG 反应的时间过程。
使用自动化检测方法“雅培 SARS-CoV-2 IgG”和“MAGLUMI 2019-nCoV IgG”，对 55 例 COVID-19 患者的 103 份标本（从症状出现开始的时间：3-187 天）进行 IgG 测量。
两种方法的一致性为 90.3%，但定量相关性虽然显著，但结果分散。所有标本在 17 天后均呈阳性。然而，IgG 的中位数浓度迅速增加至 20 天，而 Maglumi IgG 则下降，Abbott IgG 则呈持续趋势直至 85 天，然后缓慢下降。
SARS-CoV-2 抗体 IgG 的滴度可能会显著且快速下降，但取决于用于检测的方法，其时间过程则非常不同。
