Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Chemistry, Tulane University, New Orleans, LA, USA.
Mol Divers. 2022 Feb;26(1):183-190. doi: 10.1007/s11030-020-10173-4. Epub 2021 Jan 3.
Herein, a convenient and efficient synthesis of 7-benzoyl-6-(aryl)-6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-one derivatives was achieved from the reaction of isoquinolinium N-ylides, aromatic aldehydes, and heterocyclic 1,3-dicarbonyl compounds via one-pot three-component diastereoselective domino reaction in good-to-excellent yields. The advantages of this protocol are easily available starting materials, operational simplicity, and avoidance of hazardous organic solvents and catalyst. The synthesized products were characterized by IR, H NMR, C NMR and mass spectra. Additionally, the conclusive structure of target compounds was confirmed by X-Ray diffraction analysis.
本文实现了一种简便高效的合成 7-苯甲酰基-6-(芳基)-6,7-二氢-5H-呋喃并[2,3-d]噻唑并[3,2-a]嘧啶-5-酮衍生物的方法，该方法是通过一锅法三组分非对映选择性稠合反应，由异喹啉𬭩 N-叶立德、芳香醛和杂环 1,3-二羰基化合物反应得到，产率良好至优秀。该方法的优点是起始原料易得、操作简单、避免了使用危险的有机溶剂和催化剂。所合成的产物通过 IR、H NMR、C NMR 和质谱进行了表征。此外，通过 X 射线衍射分析确认了目标化合物的确定结构。
