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高效三组分一锅法合成 5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-甲腈。

An efficient three component one-pot synthesis of 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles.

机构信息

College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China.

出版信息

Molecules. 2012 Feb 14;17(2):1860-9. doi: 10.3390/molecules17021860.

DOI:10.3390/molecules17021860
PMID:22334064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6268426/
Abstract

A series of novel 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles were synthesized by a one-pot reaction of 3-amino-1,2,4-triazole, malononitrile and aryl aldehydes in the presence of 20 mol% NaOH in ethanol under heating or ultrasonic irradiation. The structures of the target compounds were confirmed by inspection of their (1)H- NMR, (13)C-NMR, IR and MS spectra. The advantages of this method are short reaction times, good yields, high selectivity and operational simplicity.

摘要

一系列新型 5-氨基-7-芳基-7,8-二氢-[1,2,4]三唑并[4,3-a]嘧啶-6-甲腈是通过在乙醇中存在 20mol%NaOH 的条件下，将 3-氨基-1,2,4-三唑、丙二腈和芳醛一锅反应，加热或超声辐射下合成的。目标化合物的结构通过其 (1)H-NMR、(13)C-NMR、IR 和 MS 光谱进行了确认。该方法的优点是反应时间短、产率高、选择性好、操作简单。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04a/6268426/ecf6270be577/molecules-17-01860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04a/6268426/ccfa19e543f1/molecules-17-01860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04a/6268426/ecf6270be577/molecules-17-01860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04a/6268426/ccfa19e543f1/molecules-17-01860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c04a/6268426/ecf6270be577/molecules-17-01860-g002.jpg

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