迷迭香几种化学化合物对阿尔茨海默病的治疗作用。

Therapeutic Properties of Several Chemical Compounds of Salvia officinalis L. in Alzheimer's Disease.

机构信息

Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest, Romania.

出版信息

Mini Rev Med Chem. 2021;21(12):1421-1430. doi: 10.2174/1389557521999201230200209.

DOI:10.2174/1389557521999201230200209

PMID:33390133

Abstract

BACKGROUND

Currently, the pharmacological management of Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms and severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, particularly, certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics.

OBJECTIVES

In this paper, we have summarized data from the recent literature on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease.

METHODS

In addition to the wide range of experimental methods performed in vivo and in vitro, we also presented some in silico studies of medicinal compounds.

RESULTS

Through this mini-review, we presented the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease.

CONCLUSION

Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

摘要

背景

目前，阿尔茨海默病的药物治疗基于几种化学结构，代表物为乙酰胆碱酯酶和 N-甲基-D-天冬氨酸（NMDA）受体配体，但分子机制仍不清楚，且副作用严重。出于这个原因，阿尔茨海默病治疗的一个挑战仍然是确定具有较低副作用的新药。最近，天然化合物，特别是薄荷、鼠尾草、葡萄、沙棘等植物精油中鉴定出的某些化学化合物，作为可能的治疗方法引起了越来越多的关注。