Wang Feiyan, Li Chenyi, Yu Haizheng, Yang Dongfeng, Ye Ji, Zhang Lei
Innovative Drug Research Center, College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou, China.
State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai, China.
Front Plant Sci. 2025 Jul 4;16:1613313. doi: 10.3389/fpls.2025.1613313. eCollection 2025.
is an important dietary supplement that is widely used as a flavor regulator and plays an important role in the prevention and treatment of neurodegenerative diseases. Bunge is a famous Chinese herbal medicine for treating cardiovascular diseases. Secondary metabolites with diverse structures endow the two species with various edible and medicinal values. However, the differences in secondary metabolites between the leaves of and are still unclear. Herein, FlavourSpec combined with spatial metabolomics was used to explore the distribution patterns of secondary metabolites including volatile and non-volatile components. The results indicated that the chemical compositions of the two species were significantly different. Specifically, Bunge contained high levels of phenolic acid components with a furan ring that can hardly be detected in The volatile small molecules as well as carnosic acid and its derivatives were found to be major components of leaves. Because of the long-term exposure of leaves to ultraviolet radiation and the same environmental stress, carnosic acid and its derivatives exhibit widespread distribution characteristics in leaves. The work explored the similarities and differences in secondary metabolites of and Bunge, providing not only the material basis to develop the application value in dietary nutrition, but also a theoretical foundation for the development and utilization of medicinal resources of .
是一种重要的膳食补充剂，被广泛用作风味调节剂，在神经退行性疾病的预防和治疗中发挥着重要作用。 是治疗心血管疾病的著名中药材。结构多样的次生代谢产物赋予了这两个物种各种食用和药用价值。然而， 和 叶片中次生代谢产物的差异仍不清楚。在此，采用FlavourSpec结合空间代谢组学方法，探索包括挥发性和非挥发性成分在内的次生代谢产物的分布模式。结果表明，这两个 物种的化学成分存在显著差异。具体而言， 含有高水平的带有呋喃环的酚酸成分，而在 中几乎检测不到；挥发性小分子以及肌醇六磷酸及其衍生物被发现是 叶片的主要成分。由于叶片长期暴露于紫外线辐射和相同的环境压力下，肌醇六磷酸及其衍生物在 叶片中呈现出广泛的分布特征。这项工作探索了 和 的次生代谢产物的异同，不仅为开发膳食营养中的应用价值提供了物质基础，也为 的药用资源开发利用提供了理论依据。
