Department of Oral Medicine, Basic Medical College, Capital Medical University, Beijing 100069, China.
Undergraduate Student of 2018 Eight Program of Clinical Medicine, Peking University Health Science Center, Beijing, 100081, China.
Int J Biol Sci. 2021 Jan 1;17(1):204-219. doi: 10.7150/ijbs.51362. eCollection 2021.
The intestine serves as an important digestive and the largest immune organ in the body. Interleukin-6(IL-6), an important mediator of various pathways, participates in the interactions between different kinds of cells and closely correlates with intestinal physiological and pathological condition. In this review we summarize the signaling pathways of IL-6 and its functions in maintaining intestinal homeostasis. We also explored its relation with nervous system and highlight its potential role in Parkinson's disease. Based on its specialty of the double-side influences on intestinal tumors and inflammation, we summarize how they are done through distinctive process.
肠道是人体重要的消化器官和最大的免疫器官。白细胞介素-6（IL-6）作为多种途径的重要介质，参与不同细胞间的相互作用，与肠道的生理和病理状态密切相关。本文综述了 IL-6 的信号通路及其在维持肠道内环境稳定中的作用，探讨了其与神经系统的关系，并强调了其在帕金森病中的潜在作用。基于其对肠道肿瘤和炎症的双重影响，我们总结了它们通过不同的过程发挥作用的机制。
