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益生菌GG促进小鼠肠道微生物群多样性和T细胞分化。

Probiotic GG Promotes Mouse Gut Microbiota Diversity and T Cell Differentiation.

作者信息

Shi Chun-Wei, Cheng Ming-Yang, Yang Xin, Lu Yi-Yuan, Yin Hong-Duo, Zeng Yan, Wang Ru-Yu, Jiang Yan-Long, Yang Wen-Tao, Wang Jian-Zhong, Zhao Dan-Dan, Huang Hai-Bin, Ye Li-Ping, Cao Xin, Yang Gui-Lian, Wang Chun-Feng

机构信息

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China.

Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, Changchun, China.

出版信息

Front Microbiol. 2020 Dec 17;11:607735. doi: 10.3389/fmicb.2020.607735. eCollection 2020.

DOI:10.3389/fmicb.2020.607735
PMID:33391230
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7773731/
Abstract

Lactic acid bacteria (LAB) are the primary genera of the intestinal flora and have many probiotic functions. In the present study, (LGG) ATCC 53103 was used to treat BALB/c mice. After LGG intervention, both low and high LGG doses were shown to improve the observed OTU, Chao1, ACE, and Shannon indices, while the Simpson index decreased, demonstrating that LGG can promote intestinal microbiota abundance and diversity. Furthermore, LGG treatment increased the abundances of intestinal , and while reducing that of . In addition to its effect on gut the microbiota, LGG could also regulate the host immune system. In the present study, we showed that LGG could affect the percentage of CD3 T lymphocytes in the spleens (SPLs), mesenteric lymph nodes (MLNs), Peyer's patches (PPs) and lamina propria lymphocytes (LPLs) of mice, including total CD3 T, CD3CD4 T, and CD3CD8 T lymphocytes. Furthermore, LGG could effectively increase the expression of Th1-type cytokines (IFN-γ) and Th2 cytokines (IL-4) in CD4 T cells, indicating that the proportion of Th1 and Th2 cells in mice with LGG treatment was in a high equilibrium state compared to the control group. In addition, the IFN-γ/IL-4 ratio was greater than 1 in mice with LGG intervention, suggesting that LGG tends to mediate the Th1 immune response. The results of the present study also showed that LGG upregulated the expression of IL-17 in CD4 T cells and regulated the percentage of CD4CD25Foxp3 Treg cells in various secondary immunological organs, indicating that LGG may promote the balance of Th-17 and Treg cells.

摘要

乳酸菌（LAB）是肠道菌群的主要属类，具有多种益生菌功能。在本研究中，使用鼠李糖乳杆菌（LGG）ATCC 53103处理BALB/c小鼠。LGG干预后，低剂量和高剂量LGG均显示可改善观察到的OTU、Chao1、ACE和香农指数，而辛普森指数降低，表明LGG可促进肠道微生物群的丰度和多样性。此外，LGG处理增加了肠道中、和的丰度，同时降低了的丰度。除了对肠道微生物群有影响外，LGG还可调节宿主免疫系统。在本研究中，我们表明LGG可影响小鼠脾脏（SPL）、肠系膜淋巴结（MLN）、派尔集合淋巴结（PP）和固有层淋巴细胞（LPL）中CD3 T淋巴细胞的百分比，包括总CD3 T、CD3CD4 T和CD3CD8 T淋巴细胞。此外，LGG可有效增加CD4 T细胞中Th1型细胞因子（IFN-γ）和Th2细胞因子（IL-4）的表达，表明与对照组相比，接受LGG处理的小鼠中Th1和Th2细胞的比例处于高度平衡状态。此外，LGG干预小鼠的IFN-γ/IL-4比值大于1，表明LGG倾向于介导Th1免疫反应。本研究结果还表明，LGG上调CD4 T细胞中IL-17的表达，并调节各种二级免疫器官中CD4CD25Foxp3 Treg细胞的百分比，表明LGG可能促进Th-17和Treg细胞的平衡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/e25359f1b902/fmicb-11-607735-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/fd145103f3cf/fmicb-11-607735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/aeab6201cb17/fmicb-11-607735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/d74ce7c4ed86/fmicb-11-607735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/e546351f72d9/fmicb-11-607735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/73ed154b2c41/fmicb-11-607735-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/0082f43e465c/fmicb-11-607735-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/3d950fa1b3f1/fmicb-11-607735-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/d97b908d4b28/fmicb-11-607735-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/e25359f1b902/fmicb-11-607735-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/fd145103f3cf/fmicb-11-607735-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/aeab6201cb17/fmicb-11-607735-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/d74ce7c4ed86/fmicb-11-607735-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/e546351f72d9/fmicb-11-607735-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/73ed154b2c41/fmicb-11-607735-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/0082f43e465c/fmicb-11-607735-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/3d950fa1b3f1/fmicb-11-607735-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/d97b908d4b28/fmicb-11-607735-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fe4/7773731/e25359f1b902/fmicb-11-607735-g009.jpg

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本文引用的文献

[1]
Effect of Lactobacillus rhamnosus on the development of B cells in gut-associated lymphoid tissue of BALB/c mice.

J Cell Mol Med. 2020-8

[2]
The regulatory effect of Lactobacillus rhamnosus GG on T lymphocyte and the development of intestinal villi in piglets of different periods.

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Lactobacillus rhamnosus GG supplementation modulates the gut microbiota to promote butyrate production, protecting against deoxynivalenol exposure in nude mice.

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Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation.

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