O'Brien Sofie A, Hu Wei-Shou
Department of Biomedical Engineering and Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455-0132 USA.
Curr Opin Chem Eng. 2020 Dec;30. doi: 10.1016/j.coche.2020.100663. Epub 2020 Dec 1.
Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.
细胞培养工艺用于生产绝大多数蛋白质治疗药物，全球每年的价值超过1800亿美元。十多年来，这些工艺已经变得高产。为了进一步提高资本效率，一次性设备和连续处理的采用有所增加，同时也更多地探索在线传感、各种组学工具和细胞工程，以提高工艺可控性和产品质量一致性。蛋白质生物制品细胞培养工艺方面的这些成就将有助于加速病毒和细胞治疗应用的生物工艺进步。
