用于椎间盘组织工程的电纺丝和3D生物打印技术
Electrospinning and 3D bioprinting for intervertebral disc tissue engineering.
作者信息
De Pieri Andrea, Byerley Ann M, Musumeci Catherine R, Salemizadehparizi Fatemeh, Vanderhorst Maya A, Wuertz-Kozak Karin
机构信息
Department of Biomedical Engineering Rochester Institute of Technology (RIT) Rochester New York USA.
Schön Clinic Munich Harlaching, Spine Center Academic Teaching Hospital and Spine Research Institute of the Paracelsus Medical University Salzburg (AU) Munich Germany.
出版信息
JOR Spine. 2020 Aug 6;3(4):e1117. doi: 10.1002/jsp2.1117. eCollection 2020 Dec.
Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell-seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation.
椎间盘退变是腰痛的主要原因,也是巨大的社会经济负担。目前的保守治疗和手术治疗无法恢复天然组织结构和功能。组织工程策略,尤其是基于3D生物打印和静电纺丝的策略,通过制造植入细胞的支架来复制椎间盘细胞外基质的结构,已成为可能的替代方案。在本综述中,我们概述了3D生物打印和静电纺丝在治疗椎间盘退变方面的最新进展和局限性,重点关注可能有助于其临床转化的未来研究领域。
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