Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Acta Biomater. 2023 Sep 1;167:1-15. doi: 10.1016/j.actbio.2023.06.012. Epub 2023 Jun 16.
Low back pain is a major public health concern experienced by 80% of the world's population during their lifetime, which is closely associated with intervertebral disc (IVD) herniation. IVD herniation manifests as the nucleus pulposus (NP) protruding beyond the boundaries of the intervertebral disc due to disruption of the annulus fibrosus (AF). With a deepening understanding of the importance of the AF structure in the pathogenesis of intervertebral disc degeneration, numerous advanced therapeutic strategies for AF based on tissue engineering, cellular regeneration, and gene therapy have emerged. However, there is still no consensus concerning the optimal approach for AF regeneration. In this review, we summarized strategies in the field of AF repair and highlighted ideal cell types and pro-differentiation targeting approaches for AF repair, and discussed the prospects and difficulties of implant systems combining cells and biomaterials to guide future research directions. STATEMENT OF SIGNIFICANCE: Low back pain is a major public health concern experienced by 80% of the world's population during their lifetime, which is closely associated with intervertebral disc (IVD) herniation. However, there is still no consensus concerning the optimal approach for annulus fibrosus (AF) regeneration. In this review, we summarized strategies in the field of AF repair and highlighted ideal cell types and pro-differentiation targeting approaches for AF repair, and discussed the prospects and difficulties of implant systems combining cells and biomaterials to guide future research directions.
腰痛是全球 80%的人在其一生中都会经历的主要公共健康问题，它与椎间盘（IVD）突出密切相关。IVD 突出表现为由于纤维环（AF）破裂，髓核（NP）突出到椎间盘之外。随着人们对 AF 结构在椎间盘退变发病机制中的重要性认识的加深，出现了许多基于组织工程、细胞再生和基因治疗的针对 AF 的先进治疗策略。然而，对于 AF 再生的最佳方法仍没有共识。在这篇综述中，我们总结了 AF 修复领域的策略，并强调了 AF 修复的理想细胞类型和促进分化的靶向方法，讨论了结合细胞和生物材料的植入系统的前景和困难，以指导未来的研究方向。
腰痛是全球 80%的人在其一生中都会经历的主要公共健康问题，它与椎间盘（IVD）突出密切相关。然而，对于纤维环（AF）再生的最佳方法仍没有共识。在这篇综述中，我们总结了 AF 修复领域的策略，并强调了 AF 修复的理想细胞类型和促进分化的靶向方法，讨论了结合细胞和生物材料的植入系统的前景和困难，以指导未来的研究方向。
