Guo Xingyu, Lu Zian, Xiao Wenbiao, Huang Han, Wu Jianwei, Zou Fei, Ma Xiaosheng, Chen Zhenhao, Wang Hongli, Jiang Jianyuan
Department of Orthopedics, Huashan Hospital, Fudan University, 12 Wulumuqizhong Rd, Shanghai, 200040 China.
Cell Mol Bioeng. 2025 Mar 16;18(2):109-121. doi: 10.1007/s12195-025-00844-3. eCollection 2025 Apr.
The annulus fibrosus (AF), as an important component of the intervertebral disc (IVD), contributes to the structural integrity and functional normality of IVD. Degenerative disc diseases (DDD), due to AF impairment, are common problems that could lead to low back pain or neck pain, resulting in considerable disability and financial costs globally. The exact causes and underlying mechanisms of AF impairment, however, remain complex and unclear.
A literature search was conducted to identify relevant articles published between 1952 and 2024. We summarize the current literature on the potential etiologies of AF damage, while also providing a brief overview of the basic characteristics of the AF and current therapeutic strategies for AF impairment.
The findings suggest that several factors could induce or exacerbate AF impairment. We categorize them into distinct groups as physical and chemical stimuli, nutritional or metabolic disorders, immune and inflammatory responses, and genetic abnormalities.
Various factors could lead to AF impairment, such as particular physical and chemical stimuli, nutritional or metabolic disorders, immune and inflammatory responses, and genetic abnormalities. Meanwhile, enhancing our understanding and management of AF impairment could help discover potential preventive or therapeutic interventions for DDD.
纤维环（AF）作为椎间盘（IVD）的重要组成部分，有助于维持IVD的结构完整性和功能正常。由于AF受损导致的椎间盘退变疾病（DDD）是常见问题，可能会导致腰痛或颈痛，在全球范围内造成相当大的残疾和经济成本。然而，AF受损的确切原因和潜在机制仍然复杂且不明。
进行文献检索以确定1952年至2024年间发表的相关文章。我们总结了当前关于AF损伤潜在病因的文献，同时简要概述了AF的基本特征以及目前针对AF损伤的治疗策略。
研究结果表明，有几个因素可能诱发或加剧AF损伤。我们将它们分为不同类别，即物理和化学刺激、营养或代谢紊乱、免疫和炎症反应以及基因异常。
各种因素可能导致AF损伤，例如特定的物理和化学刺激、营养或代谢紊乱、免疫和炎症反应以及基因异常。同时，加强我们对AF损伤的理解和管理有助于发现针对DDD的潜在预防或治疗干预措施。
