School of Medicine and Health Sciences, The George Washington University, Washington, DC, 20006, USA.
Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, MD, 20850, USA.
Cancer Causes Control. 2021 Mar;32(3):221-230. doi: 10.1007/s10552-020-01376-z. Epub 2021 Jan 4.
Previous studies estimate translation of research evidence into practice takes 17 years. However, this estimate is not specific to cancer control evidence-based practices (EBPs), nor do these studies evaluate variation in the translational process. We examined the translational pathway of cancer control EBPs.
We selected five cancer control EBPs where data on uptake were readily available. Years from landmark publication to clinical guideline issuance to implementation, defined as 50% uptake, were measured. The translational pathway for each EBP was mapped and an average total time across EBPs was calculated.
Five cancer control EBPs were included: mammography, clinicians' advice to quit smoking, colorectal cancer screening, HPV co-testing, and HPV vaccination. Time from publication to implementation ranged from 13 to 21 years, averaging 15 years. Time from publication to guideline issuance ranged from 3 to 17 years, and from guideline issuance to implementation, - 4 to 12 years. Clinician's advice to quit smoking, HPV co-testing, and HPV vaccination were most rapidly implemented; colorectal cancer screening and mammography were slowest to implement.
The average time to implementation was 15 years for the five EBPs we evaluated, a marginal improvement from prior findings. Although newer EBPs such as HPV vaccination and HPV co-testing were faster to implement than other EBPs, continued efforts in implementation science to speed research to practice are needed.
先前的研究估计，将研究证据转化为实践需要 17 年。然而，这一估计并不特定于癌症控制循证实践（EBP），也没有研究评估转化过程中的变化。我们研究了癌症控制 EBP 的转化途径。
我们选择了 5 种癌症控制 EBP，这些 EBP 的采用数据易于获取。从具有里程碑意义的出版物到临床指南发布再到实施的年限（定义为 50%的采用率）进行了测量。对每个 EBP 的转化途径进行了映射，并计算了 EBP 之间的平均总时间。
纳入了 5 种癌症控制 EBP：乳房 X 光检查、医生建议戒烟、结直肠癌筛查、HPV 联合检测和 HPV 疫苗接种。从发表到实施的时间范围从 13 年到 21 年不等，平均为 15 年。从发表到指南发布的时间范围从 3 年到 17 年不等，从指南发布到实施的时间范围从 4 年到 12 年不等。医生建议戒烟、HPV 联合检测和 HPV 疫苗接种实施最快；结直肠癌筛查和乳房 X 光检查实施最慢。
我们评估的 5 种 EBP 的实施平均时间为 15 年，比先前的发现略有改善。尽管 HPV 疫苗接种和 HPV 联合检测等更新的 EBP 比其他 EBP 实施更快，但仍需要在实施科学方面继续努力，以加快研究向实践的转化。
Zotero 插件