Elabbadi Alexandre, Turpin Matthieu, Gerotziafas Grigoris T, Teulier Marion, Voiriot Guillaume, Fartoukh Muriel
Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Service de médecine intensive réanimation, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Thrombosis Center, Service D'Hématologie Biologique Hôpital Tenon, Paris, France.
Infection. 2021 Jun;49(3):559-562. doi: 10.1007/s15010-020-01553-x. Epub 2021 Jan 3.
Severe 2019 novel coronavirus infectious disease (COVID-19) with pneumonia is associated with high rates of admission to the intensive care unit (ICU). Bacterial coinfection has been reported to be rare. We aimed at describing the rate of bacterial coinfection in critically ill adult patients with severe COVID-19 pneumonia. All the patients with laboratory-confirmed severe COVID-19 pneumonia admitted to the ICU of Tenon University-teaching hospital, from February 22 to May 7th, 2020 were included. Respiratory tract specimens were obtained within the first 48 h of ICU admission. During the study period, 101 patients were referred to the ICU for COVID-19 with severe pneumonia. Most patients (n = 83; 82.2%) were intubated and mechanically ventilated on ICU admission. Overall, 20 (19.8%) respiratory tract specimens obtained within the first 48 h. Staphylococcus aureus was the main pathogen identified, accounting for almost half of the early-onset bacterial etiologies. We found a high prevalence of early-onset bacterial coinfection during severe COVID-19 pneumonia, with a high proportion of S. aureus. Our data support the current WHO guidelines for the management of severe COVID-19 patients, in whom antibiotic therapy directed to respiratory pathogens is recommended.
伴有肺炎的2019新型冠状病毒重症感染疾病（COVID-19）与重症监护病房（ICU）的高收治率相关。据报道，细菌合并感染较为罕见。我们旨在描述重症成年COVID-19肺炎患者的细菌合并感染率。纳入了2020年2月22日至5月7日入住特农大学教学医院ICU的所有实验室确诊的重症COVID-19肺炎患者。在入住ICU的头48小时内采集呼吸道标本。在研究期间，101例因重症肺炎COVID-19被转诊至ICU。大多数患者（n = 83；82.2%）在入住ICU时进行了气管插管和机械通气。总体而言，在头48小时内采集了20份（19.8%）呼吸道标本。金黄色葡萄球菌是主要鉴定出的病原体，占早期细菌病因的近一半。我们发现重症COVID-19肺炎期间早期细菌合并感染的患病率很高，其中金黄色葡萄球菌占比很大。我们的数据支持世界卫生组织目前针对重症COVID-19患者的管理指南，即建议针对呼吸道病原体进行抗生素治疗。
