Department of Periodontology, Oral Medicine and Oral Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
J Clin Periodontol. 2021 Apr;48(4):492-502. doi: 10.1111/jcpe.13419. Epub 2021 Feb 2.
To determine the potential anti-inflammatory effect of a multimodal periodic fasting programme on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS).
A total of 47 patients were recruited and hospitalized in an integrative ward for an intensified two-week multimodal fasting, diet and lifestyle programme. Patients were periodontally examined at baseline (t1), after the 2-week fasting protocol (t2) and, subsequently, 4 months after fasting (t3). The following parameters were determined: periodontal screening index (PSI), bleeding on probing (BOP), gingival crevicular fluid volume (GCF), plaque index (PI), C-reactive protein (CRP), blood pressure (BP), waist circumference (WC), fasting glucose (FGLU), triglycerides (TRG), high-density lipoprotein (HDL) and HbA1c.
A total of 28 female and 8 male patients fulfilled the defined criteria for MetS and were analysed separately by gender. At t2, BOP and GCF were reduced when compared to t1 (median: t2 = 39; t1 = 33.1%; p < .001 and t2 = 73.9; t1 = 59.3 Periotron units p = .02, respectively). BOP reduction correlated to FGLU (R = .37, p = .049) and weight reduction (R = .4, p = .04).
This study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.
确定多模式周期性禁食方案对代谢综合征（MetS）住院患者牙周炎替代指标的潜在抗炎作用。
共招募了 47 名患者，并将其收治在一个综合病房，接受为期两周的强化多模式禁食、饮食和生活方式方案。患者在基线（t1）、两周禁食方案后（t2）以及随后的禁食 4 个月后（t3）进行牙周检查。测定以下参数：牙周筛查指数（PSI）、探诊出血（BOP）、龈沟液量（GCF）、菌斑指数（PI）、C 反应蛋白（CRP）、血压（BP）、腰围（WC）、空腹血糖（FGLU）、甘油三酯（TRG）、高密度脂蛋白（HDL）和 HbA1c。
共有 28 名女性和 8 名男性患者符合 MetS 的定义标准，并分别按性别进行分析。与 t1 相比，t2 时 BOP 和 GCF 降低（中位数：t2 = 39；t1 = 33.1%；p <.001 和 t2 = 73.9；t1 = 59.3 Periotron 单位 p =.02）。BOP 降低与 FGLU（R =.37，p =.049）和体重减轻（R =.4，p =.04）相关。
本研究首次表明，在 MetS 女性患者中进行临床监督的周期性禁食可能有助于减轻牙周炎。
