Pappe C L, Maetschker J, Dujardin S, Peters B, Pivovarova-Ramich O, Kandil F, Michalsen A, Breinlinger C, Steckhan N, Koppold D, Dommisch H
Department of Periodontology, Oral Medicine and Oral Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Prosthetic Dentistry, University School of Dental Medicine, Martin Luther University Halle-Wittenberg, Halle, Germany.
J Clin Periodontol. 2025 May;52(5):681-694. doi: 10.1111/jcpe.14151. Epub 2025 Mar 9.
To evaluate the effect of religious Bahá'í dry fasting (BF) or 16:8 time-restricted eating (TRE) compared with a regular diet (CG) on periodontal parameters during a modified experimentally induced gingivitis.
All participants were asked to refrain from oral hygiene (3 sextant) for 9 days (T1-T2) and were followed for a total of 19 days (T3) while adhering to fasting or a regular diet and resuming oral hygiene. The primary outcome was bleeding on probing in the test sextant (BOP_s), Rustogi plaque index (RPI), gingival crevicular fluid (GCF), blood pressure (BP), body weight (BW), HbA1c and C-reactive protein (CRP) were measured (T1-T3) and ANCOVA and post hoc comparison were applied.
Sixty-six healthy participants were recruited. Forty-three were randomly assigned to TRE (n = 22) and CG (n = 21), while 23 followed BF, avoiding food and drinks during the day. At T2, BF demonstrated significantly less increase in BOP_s, and GCF increased in CG only. Analysis revealed significant differences in change for BOP_s between BF and CG (-9.48% [-17.18; -1.79]) and BF and TRE (-9.19% [-15.07; -3.32]) as well as for GCF between BF and CG (-0.06 μL [-7.22; -0.66]) and TRE and CG (-0.08 μL [-0.17; -0.00]).
This study indicates beneficial effects of different fasting protocols on oral experimental gingivitis and metabolic parameters, but results are limited by randomisation issues and potential bias in the BF group.
评估巴哈伊宗教干禁食（BF）或16:8限时进食（TRE）与常规饮食（CG）相比，在改良实验性龈炎期间对牙周参数的影响。
所有参与者被要求在9天内（T1 - T2）停止对3个牙面的口腔卫生维护，在坚持禁食或常规饮食并恢复口腔卫生的情况下，共随访19天（T3）。主要观察指标为测试牙面探诊出血（BOP_s），测量Rustogi菌斑指数（RPI）、龈沟液（GCF）、血压（BP）、体重（BW）、糖化血红蛋白（HbA1c）和C反应蛋白（CRP）（T1 - T3），并应用协方差分析和事后比较。
招募了66名健康参与者。43人被随机分配到TRE组（n = 22）和CG组（n = 21），23人进行BF，白天避免食物和饮料。在T2时，BF组的BOP_s增加显著较少，且仅CG组的GCF增加。分析显示，BF组与CG组之间BOP_s的变化存在显著差异（-9.48% [-17.18; -1.79]），BF组与TRE组之间也存在显著差异（-9.19% [-15.07; -3.32]）；BF组与CG组之间GCF的变化存在显著差异（-0.06 μL [-7.22; -0.66]），TRE组与CG组之间也存在显著差异（-0.08 μL [-0.17; -0.00]）。
本研究表明不同禁食方案对口腔实验性龈炎和代谢参数有有益影响，但结果受随机化问题和BF组潜在偏倚的限制。
