New York Nutrition Obesity Research Center, Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Pediatr Obes. 2021 Jul;16(7):e12767. doi: 10.1111/ijpo.12767. Epub 2021 Jan 4.
LIFT (Lifestyle Intervention for Two) trial found that intervening in women with overweight and obesity through promoting healthy diet and physical activity to control gestational weight gain (GWG) resulted in neonates with greater weight, lean mass and head circumference and similar fat mass at birth. Whether these neonate outcomes are sustained at 1-year was the focus of this investigation.
Measures included body composition by PEA POD air displacement plethysmography (ADP) and Echo Infant quantitative magnetic resonance (QMR) and head circumference at birth (n = 169), 14 (n = 136) and 54 weeks (n = 137). Differences in fat and lean mass between lifestyle intervention (LI) and Usual care (UC) groups were examined using ANCOVA adjusting for maternal age and BMI, GWG, offspring sex and age.
Compared to UC, LI infants had similar weight (112 ± 131 g; P = .40), fat mass (14 ± 80 g; P = .86), lean mass (100 ± 63 g; P = .12) at 14 weeks and similar weight (168 ± 183 g; P = .36), fat mass (148 ± 124 g; P = .24), lean mass (117 ± 92 g; P = .21) at 54 weeks. Head circumference was greater in LI at 54 weeks (0.46 ± 2.1 cm P = .03).
Greater lean mass observed at birth in LI offspring was not sustained at 14 and 54 weeks, whereas the greater head circumference in LI offspring persisted at 54 weeks.
LIFT（生活方式干预二人组）试验发现，通过促进健康饮食和体育活动来控制妊娠体重增加（GWG），对超重和肥胖的女性进行干预，导致新生儿体重、瘦体重和头围增加，脂肪量相似。这些新生儿结局是否在 1 岁时持续是本研究的重点。
通过 PEA POD 空气置换体积描记法（ADP）和 Echo Infant 定量磁共振（QMR）测量身体成分，并在出生时（n=169）、14 周（n=136）和 54 周（n=137）测量头围。使用 ANCOVA 调整母亲年龄和 BMI、GWG、后代性别和年龄后，比较生活方式干预（LI）和常规护理（UC）组之间的脂肪和瘦体重差异。
与 UC 相比，LI 组婴儿在 14 周时体重（112±131 克；P=0.40）、脂肪量（14±80 克；P=0.86）、瘦体重（100±63 克；P=0.12）相似，在 54 周时体重（168±183 克；P=0.36）、脂肪量（148±124 克；P=0.24）、瘦体重（117±92 克；P=0.21）相似。LI 组婴儿在 54 周时头围较大（0.46±2.1 厘米，P=0.03）。
LI 组后代出生时观察到的较大的瘦体重在 14 周和 54 周时没有持续，而 LI 组后代较大的头围在 54 周时持续存在。
