Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13 Wuhan 430030, PR China; Key Laboratory of Environment & Health (Huazhong University of Science and Technology), Ministry of Education, State Environmental Protection Key Laboratory of Environment and Health (Wuhan) and State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China.
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13 Wuhan 430030, PR China; Key Laboratory of Environment & Health (Huazhong University of Science and Technology), Ministry of Education, State Environmental Protection Key Laboratory of Environment and Health (Wuhan) and State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China; Wuhan Prevention and Treatment Center for Occupational Diseases, Wuhan 430015, Hubei, PR China.
Ecotoxicol Environ Saf. 2021 Jan 15;208:111633. doi: 10.1016/j.ecoenv.2020.111633. Epub 2020 Nov 19.
Exposure to phthalates poses potential to damage multiple organs and system in the body. However, limited data are available regarding effects of seasonal exposure levels of phthalates and indicators reflecting inflammatory response. We designed a pilot study with repeated measures. We recruited 106 eligible habitants from Wuhan city, China. They completed questionnaires, physical examinations and provided urine specimens in winter and summer seasons. We found that urinary levels of low-molecular-weight phthalate metabolites were higher in summer than in winter (all P < 0.01). In winter, an interquartile range increase (1.264 μg/L) in 3-day moving average of high-molecular-weight phthalate metabolites corresponded to a 13.634% (95% CI: -22.331, -3.941) decrease in mean platelet volume, 25.879% (95% CI: -37.424, -12.204) for lymphocyte count or 10.862% (95% CI: -18.716, -2.125) for platelet count (P < 0.05 or P < 0.01). However, in summer, an interquartile range increase (1.215 μg/L) in urinary levels of high-molecular-weight phthalate metabolites corresponded to an 8.743% (95% CI: 4.217, 13.467) increase in platelet distribution width value or a 4.597% (95% CI: 2.335, 6.780) for mean platelet volume value at 3-day lag (both P < 0.01). In conclusion, phthalate exposure exhibited the potential for the activation of platelet function, particularly in winter. Seasonal variations of phthalate exposure should be considered when assessing health risk.
接触邻苯二甲酸酯有可能对体内多个器官和系统造成损害。然而，关于邻苯二甲酸酯季节性暴露水平和反映炎症反应的指标的影响，数据有限。我们设计了一项具有重复测量的试点研究。我们从中国武汉市招募了 106 名合格居民。他们在冬季和夏季完成了问卷调查、体检并提供了尿液样本。我们发现，夏季尿液中低分子量邻苯二甲酸酯代谢物水平高于冬季（均 P<0.01）。在冬季，高分子量邻苯二甲酸酯代谢物 3 天移动平均值的一个四分位间距增加（1.264μg/L）对应于平均血小板体积降低 13.634%（95%CI：-22.331，-3.941），淋巴细胞计数降低 25.879%（95%CI：-37.424，-12.204），血小板计数降低 10.862%（95%CI：-18.716，-2.125）（P<0.05 或 P<0.01）。然而，在夏季，高分子量邻苯二甲酸酯代谢物尿液水平的一个四分位间距增加（1.215μg/L）对应于血小板分布宽度值增加 8.743%（95%CI：4.217，13.467）或平均血小板体积值增加 4.597%（95%CI：2.335，6.780）在 3 天滞后时（均 P<0.01）。总之，邻苯二甲酸酯暴露具有激活血小板功能的潜力，尤其是在冬季。在评估健康风险时，应考虑邻苯二甲酸酯暴露的季节性变化。
