State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University, Kaifeng 475001, China.
Int J Mol Sci. 2020 Dec 31;22(1):354. doi: 10.3390/ijms22010354.
Environmental stresses have driven plants to develop various mechanisms to acclimate in adverse conditions. Extensive studies have demonstrated that a significant reprogramming occurs in the plant transcriptome in response to biotic and abiotic stresses. The highly conserved and large multi-subunit transcriptional co-activator of eukaryotes, known as the Mediator, has been reported to play a substantial role in the regulation of important genes that help plants respond to environmental perturbances. CDK8 module is a relatively new component of the Mediator complex that has been shown to contribute to plants' defense, development, and stress responses. Previous studies reported that CDK8 module predominantly acts as a transcriptional repressor in eukaryotic cells by reversibly associating with core Mediator. However, growing evidence has demonstrated that depending on the type of biotic and abiotic stress, the CDK8 module may perform a contrasting regulatory role. This review will summarize the current knowledge of CDK8 module as well as other previously documented Mediator subunits in plant cell signaling under stress conditions.
环境胁迫促使植物发展出各种适应不利条件的机制。大量研究表明，生物和非生物胁迫会导致植物转录组发生显著重编程。真核生物中高度保守且多亚基的转录共激活因子 Mediator 已被报道在调节有助于植物应对环境扰动的重要基因方面发挥重要作用。CDK8 模块是 Mediator 复合物的一个相对较新的组成部分，它被证明有助于植物的防御、发育和应激反应。先前的研究表明，CDK8 模块主要通过与核心 Mediator 可逆结合，在真核细胞中作为转录抑制剂发挥作用。然而，越来越多的证据表明，取决于生物和非生物胁迫的类型，CDK8 模块可能发挥相反的调节作用。本综述将总结 CDK8 模块以及其他先前报道的 Mediator 亚基在胁迫条件下植物细胞信号转导中的最新知识。
