College of Medicine, QU Health, Qatar University, Doha P.O. Box 2731, Qatar.
#2Biomedical and Pharmaceutical research Unit, QU Health, Qatar University, Doha P.O. Box 2731, Qatar.
Nutrients. 2020 Dec 31;13(1):127. doi: 10.3390/nu13010127.
Low serum 25-hydroxyvitamin D [25(OH)D] is linked to an altered lipid profile. Monocytes play an important role in inflammation and lipid metabolism. Recently, monocyte percentage to HDL-cholesterol ratio (MHR) has emerged as a novel marker of inflammation. We investigated the association between serum 25(OH)D concentrations and MHR and serum lipids in young healthy adults. Data from the Qatar Biobank were utilized to investigate the relation between serum 25(OH)D and inflammation and serum lipid concentrations in healthy Qatari adults using multivariate regression analysis. Prevalence of serum 25(OH)D concentrations <12 ng/mL (deficiency), 12-20 ng/mL (insufficiency), and ≥20 ng/mL (sufficiency) were 55.8%, 29.9%, and 14.3%, respectively. Serum 25(OH)D was significantly inversely associated with monocyte percentage, MHR, total cholesterol, LDL-cholesterol, and triacylglycerol in multivariable adjusted analysis. MHR could be a potential biomarker to predict cardiometabolic diseases among young healthy Qataris.
血清 25-羟维生素 D [25(OH)D] 水平降低与脂质谱异常有关。单核细胞在炎症和脂质代谢中起重要作用。最近，单核细胞与高密度脂蛋白胆固醇比值（MHR）已成为炎症的新型标志物。我们研究了血清 25(OH)D 浓度与 MHR 以及年轻健康成年人血清脂质之间的关系。利用卡塔尔生物库的数据，采用多元回归分析研究了血清 25(OH)D 与炎症和血清脂质浓度在健康卡塔尔成年人中的关系。血清 25(OH)D 浓度<12ng/mL（缺乏）、12-20ng/mL（不足）和≥20ng/mL（充足）的患病率分别为 55.8%、29.9%和 14.3%。在多变量调整分析中，血清 25(OH)D 与单核细胞百分比、MHR、总胆固醇、LDL-胆固醇和三酰甘油呈显著负相关。MHR 可能是预测年轻健康卡塔尔人心血管代谢疾病的潜在生物标志物。
