Department of Health Management Center, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
BMC Endocr Disord. 2023 Jul 12;23(1):149. doi: 10.1186/s12902-023-01406-2.
The primary objective of this study was to explore the association of vitamin D with the monocyte to HDL-C ratio (MHR) among medical staff in Chengdu, China.
This cross-sectional study involved 538 medical staff, including 393 females and 145 males, and included data on gender, age, body mass index, and laboratory parameters (including complete blood count, vitamin D levels, lipid, etc.). According to serum 25 (OH)D < 20 ng/ml as vitamin D deficiency, subjects were divided into two groups based on serum 25 (OH)D levels: a vitamin D deficiency group with serum 25 (OH)D < 20 ng/ml and a vitamin D sufficiency group with serum 25 (OH)D ≥ 20 ng/ml. When considering vitamin D as a categorical variable, a multivariable logistic regression analysis was conducted to assess the risk factors associated with vitamin D deficiency. On the other hand, when examining the factors influencing vitamin D levels as a continuous variable, a multiple linear regression model was utilized.
The prevalence of vitamin D deficiency was 86.25% among all the participants. Males exhibited a higher risk of vitamin D deficiency compared to females (β=0.383, P = 0.026). Vitamin D deficiency risk decreased with age (β = 0.910, P < 0.001). Additionally, elevated values of MHR were associated with an increased risk of vitamin D deficiency (β = 1.530, P = 0.019). When treating vitamin D as a continuous variable, the results of multiple linear regression revealed that age (β = 0.342, P < 0.001), and TG (β=-1.327, P = 0.010) were independent influencing factors for vitamin D levels, indicating that vitamin D levels increase with age. A reverse association between MHR and vitamin D levels demonstrated a marginal trend toward significance (β=-0.581, P = 0.052).
Vitamin D is inversely associated with MHR among young medical staff in Chengdu, China.
本研究的主要目的是探讨维生素 D 与中国成都医务人员单核细胞与高密度脂蛋白胆固醇比值（MHR）之间的关系。
本横断面研究纳入了 538 名医务人员，其中 393 名为女性，145 名为男性，研究内容包括性别、年龄、体重指数和实验室参数（包括全血细胞计数、维生素 D 水平、血脂等）。根据血清 25（OH）D<20ng/ml 为维生素 D 缺乏，将研究对象根据血清 25（OH）D 水平分为两组：血清 25（OH）D<20ng/ml 的维生素 D 缺乏组和血清 25（OH）D≥20ng/ml 的维生素 D 充足组。当考虑维生素 D 为分类变量时，采用多变量逻辑回归分析评估与维生素 D 缺乏相关的危险因素。另一方面，当作为连续变量检验影响维生素 D 水平的因素时，采用多元线性回归模型。
所有参与者中维生素 D 缺乏的患病率为 86.25%。男性患维生素 D 缺乏的风险高于女性（β=0.383，P=0.026）。维生素 D 缺乏的风险随年龄增长而降低（β=0.910，P<0.001）。此外，MHR 值升高与维生素 D 缺乏的风险增加相关（β=1.530，P=0.019）。将维生素 D 作为连续变量处理时，多元线性回归的结果表明，年龄（β=0.342，P<0.001）和甘油三酯（β=-1.327，P=0.010）是维生素 D 水平的独立影响因素，表明维生素 D 水平随年龄增长而增加。MHR 与维生素 D 水平之间呈负相关，具有显著趋势（β=-0.581，P=0.052）。
在中国成都的年轻医务人员中，维生素 D 与 MHR 呈负相关。
