肝脏驻留记忆 CD8 T 细胞：在慢性乙型肝炎病毒感染中的可能作用。
Liver-Resident Memory CD8 T Cells: Possible Roles in Chronic HBV Infection.
机构信息
Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul 06591, Korea.
出版信息
Int J Mol Sci. 2020 Dec 30;22(1):283. doi: 10.3390/ijms22010283.
Achieving a functional cure for chronic hepatitis B virus (HBV) infection or complete elimination of HBV covalently closed circular DNA (cccDNA) has been challenging in the treatment of patients with chronic HBV infection. Although novel antivirals are being investigated, improving HBV-specific adaptive immune responses is also important for durable viral clearance. Tissue-resident memory CD8 T (T) cells were recently reported as a T-cell population that resides in peripheral tissues and does not recirculate. T cells have been studied in the livers of mice and humans. Liver T cells have distinct characteristics compared to T cells in peripheral blood or other tissues, which may be associated with the unique microenvironment of the liver. In this review, we describe the characteristics of liver T cells and their implications in chronic HBV infection. We emphasize that liver T cells can be an immunotherapeutic target for the treatment of chronic HBV infection.
实现慢性乙型肝炎病毒 (HBV) 感染的功能性治愈或完全消除 HBV 共价闭合环状 DNA (cccDNA) 一直是慢性 HBV 感染患者治疗的挑战。尽管正在研究新型抗病毒药物，但改善 HBV 特异性适应性免疫反应对于持久的病毒清除也很重要。组织驻留记忆 CD8 T (T) 细胞最近被报道为一种存在于外周组织中而不循环的 T 细胞群。已经在小鼠和人类的肝脏中研究了 T 细胞。与外周血或其他组织中的 T 细胞相比，肝 T 细胞具有独特的特征，这可能与肝脏的独特微环境有关。在这篇综述中，我们描述了肝 T 细胞的特征及其在慢性 HBV 感染中的意义。我们强调，肝 T 细胞可以成为治疗慢性 HBV 感染的免疫治疗靶标。
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