Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, China.
Key Laboratory of Organ Regeneration & Transplantation of the Ministry of Education, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, China.
Cells. 2020 Dec 30;10(1):42. doi: 10.3390/cells10010042.
Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.
辐射诱导损伤是接受放疗的癌症患者的常见现象。在这种情况下，由于受伤组织或器官的再生反应没有得到很好的刺激，辐射诱导损伤可能具有难治性。间充质干细胞已成为管理辐射诱导损伤的理想候选者。此外，越来越多的证据表明，间充质干细胞衍生的外泌体对修复组织损伤具有相似的作用，主要是因为这些外泌体携带各种生物活性物质，如 miRNAs、蛋白质和脂质，它们可以影响免疫调节、血管生成以及细胞存活和增殖。尽管间充质干细胞衍生的外泌体修复辐射损伤的机制尚未完全阐明，但我们旨在将它们的生物学特征转化为辐射损伤模型，并旨在为辐射损伤的管理提供新的见解。
