Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.
Department of Periodontics, KLE Society's Institute of Dental Sciences, Bangalore, India.
Syst Rev. 2021 Jan 4;10(1):5. doi: 10.1186/s13643-020-01554-9.
The antioxidant potential of vitamin C is useful in reducing oxidative stress, free radicals, and reactive oxygen species, which may assist in the improved outcomes of periodontal therapy. This systematic review was aimed to evaluate the effectiveness of vitamin C supplementation as an adjunct to non-surgical periodontal therapy, in the management of periodontitis.
PubMed, EMBASE, Cochrane Library, and Web of Science.
Randomized controlled trials published between January 1990 and March 2020.
People 18 years and older with periodontitis.
The Critical Appraisal Skills Programme (CASP) quality appraisal tool.
The initial search yielded 441 articles out of which six studies fulfilled the inclusion criteria. Vitamin C supplementation helped improve bleeding indices in gingivitis but did not significantly lead to reduction of probing depths or clinical attachment gain for periodontitis.
Administration of vitamin C as an adjunct to non-surgical periodontal therapy did not result in clinically significant improvements in pocket probing depths at 3 months in periodontitis patients. With the limited evidence available, no recommendation can be made for supplementation of vitamin C in conjunction with initial periodontal therapy for subjects with periodontitis to improve primary treatment outcome measures.
维生素 C 的抗氧化潜力有助于减轻氧化应激、自由基和活性氧物质，这可能有助于改善牙周治疗的效果。本系统评价旨在评估维生素 C 补充作为非手术牙周治疗辅助手段，在牙周炎治疗中的有效性。
PubMed、EMBASE、Cochrane 图书馆和 Web of Science。
1990 年 1 月至 2020 年 3 月期间发表的随机对照试验。
年龄在 18 岁及以上的牙周炎患者。
关键评估技能计划（CASP）质量评估工具。
初步搜索产生了 441 篇文章，其中 6 项研究符合纳入标准。维生素 C 补充有助于改善牙龈炎的出血指数，但对牙周炎的探诊深度或临床附着丧失没有显著减少。
在牙周炎患者中，将维生素 C 作为非手术牙周治疗的辅助手段，在 3 个月时并未导致牙周袋探诊深度的临床显著改善。根据现有的有限证据，不能建议在牙周炎初始治疗中补充维生素 C 以改善主要治疗结果指标。
