Danekhu Krisha, Shrestha Sunil, Aryal Sushant, Shankar P Ravi
Cogent Health Pvt Ltd, Lalitpur, Nepal.
Nepal Health Research and Innovation Foundation, Lalitpur, Nepal.
Hosp Pharm. 2021 Jun;56(3):178-186. doi: 10.1177/0018578719883796. Epub 2019 Nov 5.
Underreporting of adverse drug reactions (ADRs) is common globally, and Nepal is not an exception to this. Health-care professionals (HCPs) play a vital role in reporting ADR during routine practice. Lack of knowledge and awareness about pharmacovigilance and reporting ADRs among HCPs may contribute to underreporting. The objective of this study was to evaluate the knowledge and perception of HCPs regarding ADR reporting and pharmacovigilance in a tertiary care teaching hospital in, Nepal. A descriptive cross-sectional study was conducted. A questionnaire was distributed to 215 HCPs (medical doctors, nurses, and pharmacists) between March and September 2018. Knowledge and perception regarding ADR reporting and pharmacovigilance were studied. Data were analyzed using IBM SPSS Statistics for Windows, Version 21.0 (IBM Corp, Armonk, New York). The HCPs included 75 medical doctors, 126 nurses, and 14 pharmacists. Majority of the participants were female (67%), and the majority of participants were not aware of pharmacovigilance. Among the participants, pharmacists were found to have better knowledge regarding pharmacovigilance. However, other HCPs (doctors and nurses) strongly agreed about the necessity of having adequate knowledge about pharmacovigilance. Out of 215, 57.7% agreed that the important benefit of reporting ADR was to identify safe drugs and improve patient safety. The main reasons for not reporting were - ADR reporting was not widely promoted by relevant authorities (47%), followed by not knowing where and how to report ADR (34.9%). However, other HCPs (doctors and nurses) strongly agreed about the necessity of having adequate knowledge about pharmacovigilance. The knowledge of HCPs on ADR reporting and pharmacovigilance was poor. Despite a low knowledge of ADR reporting and pharmacovigilance among HCPs, there was a positive perception that ADR reporting is necessary and ADR monitoring system should be established in the hospital. This study also highlights a need for future intervention studies focusing on educating HCPs about ADR and pharmacovigilance.
全球范围内，药品不良反应（ADR）的漏报现象普遍存在，尼泊尔也不例外。医疗保健专业人员（HCPs）在日常医疗实践中报告药品不良反应方面发挥着至关重要的作用。HCPs对药物警戒和报告药品不良反应缺乏了解和认识可能导致漏报。本研究的目的是评估尼泊尔一家三级护理教学医院中HCPs对药品不良反应报告和药物警戒的知识与认知。开展了一项描述性横断面研究。2018年3月至9月期间，向215名HCPs（医生、护士和药剂师）发放了问卷。研究了他们对药品不良反应报告和药物警戒的知识与认知。使用IBM SPSS Statistics for Windows 21.0版（IBM公司，纽约州阿蒙克）对数据进行分析。HCPs包括75名医生、126名护士和14名药剂师。大多数参与者为女性（67%），且大多数参与者不了解药物警戒。在参与者中，药剂师对药物警戒的了解更好。然而，其他HCPs（医生和护士）强烈认同具备足够药物警戒知识的必要性。在215名参与者中，57.7%的人认为报告药品不良反应的重要益处在于识别安全药物并提高患者安全性。未报告的主要原因是——相关部门未广泛推广药品不良反应报告（47%），其次是不知道在哪里以及如何报告药品不良反应（34.9%）。然而，其他HCPs（医生和护士）强烈认同具备足够药物警戒知识的必要性。HCPs对药品不良反应报告和药物警戒的知识掌握情况较差。尽管HCPs对药品不良反应报告和药物警戒的了解程度较低，但他们积极认为药品不良反应报告是必要的，且医院应建立药品不良反应监测系统。本研究还强调了未来有必要开展干预研究，重点是对HCPs进行药品不良反应和药物警戒方面的教育。
