生物分子凝聚物在前沿：细胞迁移与相分离相遇。
Biomolecular Condensates at the Front: Cell Migration Meets Phase Separation.
机构信息
San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Division of Neuroscience, 20132, Milano, Italy.
出版信息
Trends Cell Biol. 2021 Mar;31(3):145-148. doi: 10.1016/j.tcb.2020.12.002. Epub 2021 Jan 2.
PMID:33397597
Abstract
Liquid-liquid phase separation drives the formation of biomolecular condensates (BCs) for the spatiotemporal organization of several cellular processes. Recent evidences indicate that components of plasma-membrane-associated platforms form biomolecular condensates near focal adhesions (FAs), and suggest that phase separation regulates dynamic processes occurring at the front of migrating cells.
摘要
液-液相分离驱动了生物分子凝聚物 (BCs) 的形成，为几个细胞过程的时空组织提供了条件。最近的证据表明，质膜相关平台的成分在粘着斑 (FA) 附近形成生物分子凝聚物，并表明相分离调节了迁移细胞前缘发生的动态过程。
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