Department of Molecular Cell Biology and Immunology, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center, Vrije Universiteit, 1081HZ Amsterdam, the Netherlands.
Department of Rheumatology and Clinical Immunology, Amsterdam Infection and Immunity Institute, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.
J Immunol. 2021 Jan 15;206(2):273-281. doi: 10.4049/jimmunol.2000873.
Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid organs, providing both a structural matrix and soluble factors that regulate survival and migration of immune cells, ultimately promoting Ag encounter. In several inflamed tissues, resident fibroblasts can acquire lymphoid-stroma properties and drive the formation of ectopic aggregates of immune cells, named tertiary lymphoid structures (TLSs). Mature TLSs are functional sites for the development of adaptive responses and, consequently, when present, can have an impact in both autoimmunity and cancer conditions. In this review, we go over recent findings concerning both lymph node stromal cells and TLSs function and formation and further describe what is currently known about their role in disease, particularly their potential in tolerance.
淋巴结基质细胞在次级淋巴器官中协调适应性免疫反应，提供结构基质和可溶性因子，调节免疫细胞的存活和迁移，最终促进抗原的接触。在几个炎症组织中，驻留成纤维细胞可以获得淋巴样基质特性，并驱动免疫细胞异位聚集的形成，称为三级淋巴样结构 (TLSs)。成熟的 TLS 是适应性反应发展的功能部位，因此，当存在时，它们会对自身免疫和癌症状况产生影响。在这篇综述中，我们回顾了最近关于淋巴结基质细胞和 TLS 功能和形成的发现，并进一步描述了它们在疾病中的作用，特别是它们在耐受中的潜在作用。
