Chartier Karen G, Martinez Priscilla, Cummings Cory, Riley Brien P, Karriker-Jaffe Katherine J
School of Social Work and Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.
Alcohol Research Group, Public Health Institute, Emeryville, CA, USA.
J Community Genet. 2021 Jul;12(3):459-468. doi: 10.1007/s12687-020-00502-3. Epub 2021 Jan 4.
We assessed the feasibility and acceptability of collecting a saliva sample for DNA through the mail from a national sample of drinkers and examined whether targeted messaging would increase the response rates of Black/African American and Hispanic/Latino participants. We invited respondents from two prior national population surveys to participate in a brief telephone survey regarding recent alcohol use and to mail in a self-administered saliva sample. Blacks/African Americans, Hispanics/Latinos, and Whites had similar rates of consenting to participate. A higher proportion of respondents with a college education and a family history of alcohol problems consented. The differences in participation between respondents receiving targeted and general messaging were not statistically significant. This study provides preliminary evidence for the feasibility of recruiting diverse participants into a genetic study of alcohol use disorder.
我们评估了通过邮件从全国饮酒者样本中收集唾液样本用于DNA检测的可行性和可接受性，并研究了针对性信息传递是否会提高黑人/非裔美国人和西班牙裔/拉丁裔参与者的回复率。我们邀请了之前两项全国性人口调查的受访者参加一项关于近期饮酒情况的简短电话调查，并邮寄一份自行采集的唾液样本。黑人/非裔美国人、西班牙裔/拉丁裔和白人同意参与的比例相似。受过大学教育且有酒精问题家族史的受访者同意参与的比例更高。接受针对性信息传递和一般信息传递的受访者在参与度上的差异无统计学意义。这项研究为招募不同参与者参与酒精使用障碍基因研究的可行性提供了初步证据。
