纳米包裹（Willd.）用聚（D，L-丙交酯）纳米粒在链脲佐菌素诱导的 2 型糖尿病大鼠中诱导有效控制。
Nano-encapsulated (Willd.) using poly (D, L-lactide) nanoparticles educe effective control in streptozotocin-induced type 2 diabetic rats.
机构信息
Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, India.
出版信息
IET Nanobiotechnol. 2020 Dec;14(9):803-808. doi: 10.1049/iet-nbt.2020.0085.
Abstract
The therapeutics for type 2 diabetes mellitus has emerged in the current century towards nanomedicine incorporated with plant active compounds. In this study, loaded poly (D, L-lactide) (PLA) nanoparticles (NPs) were evaluated in vivo for their anti-hyperglycemic potency towards streptozotocin-induced type 2 diabetic rats. loaded PLA NPs were synthesised by the double solvent evaporation method using PLA polymer. The NPs were then characterised and administrated orally for 28 successive days to streptozotocin-induced diabetic rats. The PLA NPs had significant anti-diabetic effects which were equal to the existing anti-diabetic drug glibenclamide. The antidiabetic activity is due to the synergism of compounds present in stem extract of the plant which reduced the side effects and anti-diabetic.
摘要
在本世纪，治疗 2 型糖尿病的方法已经朝着结合植物活性化合物的纳米医学发展。在这项研究中，我们评估了负载 的聚（D，L-丙交酯）（PLA）纳米颗粒（NPs）在体内对链脲佐菌素诱导的 2 型糖尿病大鼠的抗高血糖作用。通过双重溶剂蒸发法使用 PLA 聚合物合成了负载的 PLA NPs。然后对 NPs 进行了表征，并连续 28 天口服给予链脲佐菌素诱导的糖尿病大鼠。PLA NPs 具有显著的抗糖尿病作用，与现有的抗糖尿病药物格列本脲相当。这种抗糖尿病活性是由于植物茎提取物中存在的化合物的协同作用，降低了副作用和抗糖尿病作用。
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