Universitat Rovira i Virgili, Department of Biochemistry and Biotechnology, Nutrigenomics Research Group, Tarragona, Spain.
Food Funct. 2021 Jan 21;12(2):815-824. doi: 10.1039/d0fo02810j. Epub 2021 Jan 5.
The body weight-lowering properties of a multifunctional ingredient (MIX) based on conjugated linoleic acid at low doses, the flavonoids proanthocyanidins and anthocyanidins and the chicken feet hydrolysate Hpp11 have been previously reported. The aim of this study was to evaluate the effect of long-term administration of MIX on other cardiometabolic risk factors associated with metabolic syndrome (MetS) in rats fed a cafeteria diet (CAF). Male Wistar rats were fed CAF for 11 weeks, and during the last 3 weeks, animals were orally administered MIX or vehicle. Lipid tolerance tests were performed before and after MIX administration. At the end of the experimental period, serum and inguinal white adipose tissue (iWAT) metabolism were analyzed by metabolomics and biochemical approaches. The metabolite signature of serum and iWAT significantly changed after 3 weeks of MIX administration, suggesting an improvement in lipid and glucose homeostasis in these animals. In addition, MIX also exhibited significant antihypertensive properties. These results suggest that MIX could be a good candidate to ameliorate the cardiometabolic risk factors related to MetS.
先前已有报道称，基于共轭亚油酸、类黄酮原花青素和花色苷以及鸡脚水解物 Hpp11 的多功能成分（MIX）具有降低体重的特性。本研究旨在评估长期给予 MIX 对喂食 cafeteria 饮食（CAF）的大鼠其他与代谢综合征（MetS）相关的心脏代谢风险因素的影响。雄性 Wistar 大鼠喂食 CAF 11 周，在最后 3 周，动物经口给予 MIX 或载体。在给予 MIX 之前和之后进行脂质耐量试验。在实验期末，通过代谢组学和生化方法分析血清和腹股沟白色脂肪组织（iWAT）代谢。MIX 给药 3 周后，血清和 iWAT 的代谢物特征明显改变，提示这些动物的脂质和葡萄糖稳态得到改善。此外，MIX 还表现出显著的降压特性。这些结果表明，MIX 可能是改善与 MetS 相关的心脏代谢风险因素的良好候选物。
