Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain.
Nutrients. 2023 Jan 15;15(2):457. doi: 10.3390/nu15020457.
Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.
高血压（HTN）是全球范围内导致过早死亡的主要原因，也是心血管疾病的主要可预防风险因素。因此，目前需要新的治疗方法来控制这种情况。在这方面，含有具有降压生物活性肽的蛋白质水解物越来越受到关注。因此，农业食品工业的副产品已成为获得这些水解物的有价值的来源，因为它们富含蛋白质且价格低廉。其中，动物来源的副产品尤为突出，因为它们在全球范围内大量产生。因此，本综述重点评估了鸡肉屠宰场副产品作为管理 HTN 的肽类来源的潜在作用。这些副产品中的许多，如血液、骨头、皮肤，特别是鸡脚，已被用于获得具有血管紧张素转换酶（ACE）抑制活性和降低血压作用的蛋白质水解物。内源性抗氧化化合物水平的提高、ACE 活性的降低以及与 HTN 相关的内皮功能障碍的改善是其作用的机制。然而，这些研究大多在动物模型中进行，需要进一步的临床研究来证实这些降压特性。这将增加这些副产品的价值，为屠宰场的循环经济模式做出贡献。
