T淋巴细胞缺陷的裸鼠对肺炎球菌的宿主防御
Host defense against the pneumococcus in T-lymphocyte-deficient, nude mice.
作者信息
Winkelstein J A, Swift A J
出版信息
Infect Immun. 1975 Nov;12(5):1222-3. doi: 10.1128/iai.12.5.1222-1223.1975.
Abstract
Resistance to pneumococcal infection was tested in T-lymphocyte-deficient, nude (nu/nu) mice. Pneumococcal serum opsonizing activity, in vivo phagocytosis of the pneumococcus, and the mean lethal dose for the pneumococcus were all found to be the same in nude mice as in control (+/+) mice. T-lymphocytes do not appear to play a significant role in the host's defense against the pneumococcus.
摘要
在T淋巴细胞缺陷的裸（nu/nu）鼠中测试了对肺炎球菌感染的抵抗力。结果发现，裸鼠的肺炎球菌血清调理活性、肺炎球菌的体内吞噬作用以及肺炎球菌的平均致死剂量与对照（+/+）鼠相同。T淋巴细胞似乎在宿主抵御肺炎球菌的防御中不发挥重要作用。
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