Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Nutrition Research Center, Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Complement Ther Med. 2021 Mar;57:102659. doi: 10.1016/j.ctim.2020.102659. Epub 2021 Jan 2.
Prostate cancer is a major malignancy, affecting men, worldwide. The protective effect of green tea consumption on prostate cancer has been reported in several studies; however, the findings are equivocal.
The aim of this study was to evaluate the effects of green tea on PSA level, by conducting a systematic review and meta-analysis of randomized controlled trials.
We searched online databases, including PubMed, Scopus, and Web of Science, up to 11 Aug 2020, to obtain relevant publications. The publication search was not limited by language or date.
A total of 2488 records were identified in the systematic search; from these, seven were included in the meta-analysis. The overall analysis showed no significant changes in PSA levels in subjects treated with green tea, (WMD: ‒0.60 ng/mL; 95 % CI: ‒1.32, 0.12 ng/mL; P = 0.104, I = 93.80 %, P heterogeneity<0.001). Subgroup analysis based on geographical location showed that green tea significantly reduced PSA level in the USA population (WMD: ‒1.02 pg/mL, 95 % CI: ‒1.30, ‒0.73, P < 0.001) compared to non-USA populations (WMD: ‒0.22 pg/mL, 95 % CI: ‒0.95, 0.50, P = 0.539) (P < 0.001).
The results of this review show that green tea has no significant effect on PSA level. However, due to the heterogeneity among studies more consistent clinical trials, with larger sample sizes are required.
前列腺癌是一种主要的恶性肿瘤，影响着全世界的男性。多项研究报道了绿茶的摄入对前列腺癌有保护作用，但研究结果存在争议。
本研究旨在通过系统评价和荟萃分析评估绿茶对 PSA 水平的影响。
我们检索了在线数据库，包括 PubMed、Scopus 和 Web of Science，检索截至 2020 年 8 月 11 日，以获取相关文献。文献检索未对语言或日期进行限制。
系统检索共识别出 2488 条记录，其中 7 条被纳入荟萃分析。总体分析显示，绿茶治疗组 PSA 水平无显著变化（WMD：-0.60ng/mL；95%CI：-1.32，0.12ng/mL；P=0.104，I=93.80%，P 异质性<0.001）。基于地理位置的亚组分析显示，与非美国人群相比，绿茶可显著降低美国人群的 PSA 水平（WMD：-1.02pg/mL；95%CI：-1.30，-0.73；P<0.001）（WMD：-0.22pg/mL；95%CI：-0.95，0.50；P=0.539）（P<0.001）。
本综述结果表明，绿茶对 PSA 水平无显著影响。然而，由于研究之间存在异质性，需要更多一致性更高的临床试验，以获得更大的样本量。
