Kumar Nagi B, Hogue Stephanie, Pow-Sang Julio, Poch Michael, Manley Brandon J, Li Roger, Dhillon Jasreman, Yu Alice, Byrd Doratha A
Cancer Epidemiology Program, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Genitourinary Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Cancers (Basel). 2022 Aug 18;14(16):3988. doi: 10.3390/cancers14163988.
Accumulating evidence supports green tea catechins (GTCs) in chemoprevention for prostate cancer (PCa), a leading cause of cancer morbidity and mortality among men. GTCs include (-)-epigallocatechin-3-gallate, which may modulate the molecular pathways implicated in prostate carcinogenesis. Prior studies of GTCs suggested that they are bioavailable, safe, and effective for modulating clinical and biological markers implicated in prostate carcinogenesis. GTCs may be of particular benefit to those with low-grade PCas typically managed with careful monitoring via active surveillance (AS). Though AS is recommended, it has limitations including potential under-grading, variations in eligibility, and anxiety reported by men while on AS. Secondary chemoprevention of low-grade PCas using GTCs may help address these limitations. When administrated orally, the gut microbiome enzymatically transforms GTC structure, altering its bioavailability, bioactivity, and toxicity. In addition to xenobiotic metabolism, the gut microbiome has multiple other physiological effects potentially involved in PCa progression, including regulating inflammation, hormones, and other known/unknown pathways. Therefore, it is important to consider not only the independent roles of GTCs and the gut microbiome in the context of PCa chemoprevention, but how gut microbes may relate to individual responses to GTCs, which, in turn, can enhance clinical decision-making.
越来越多的证据支持绿茶儿茶素（GTCs）在前列腺癌（PCa）化学预防中的作用，前列腺癌是男性癌症发病率和死亡率的主要原因。GTCs包括（-）-表没食子儿茶素-3-没食子酸酯，它可能调节与前列腺癌发生有关的分子途径。先前对GTCs的研究表明，它们具有生物利用度，安全且有效地调节与前列腺癌发生有关的临床和生物学标志物。GTCs可能对那些通常通过主动监测（AS）进行仔细监测的低级别PCa患者特别有益。尽管推荐使用AS，但它有局限性，包括潜在的分级不足、资格标准的差异以及男性在AS期间报告的焦虑。使用GTCs对低级别PCa进行二级化学预防可能有助于解决这些局限性。口服时，肠道微生物群会通过酶促作用改变GTC的结构，改变其生物利用度、生物活性和毒性。除了异源物质代谢外，肠道微生物群还有多种其他可能参与PCa进展的生理作用，包括调节炎症、激素和其他已知/未知途径。因此，重要的是不仅要考虑GTCs和肠道微生物群在PCa化学预防中的独立作用，还要考虑肠道微生物与个体对GTCs反应之间的关系，这反过来又可以增强临床决策。
