Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
School of Pharmacy, Queen's University Belfast, Belfast, UK.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 May;13(3):e1690. doi: 10.1002/wnan.1690. Epub 2021 Jan 5.
Numerous diseases have been reported to affect the lymphatic system. As such, several strategies have been developed to deliver chemotherapeutics to this specific network of tissues and associated organs. Nanotechnology has been exploited as one of the main approaches to improve the lymphatic uptake of drugs. Different nanoparticle approaches utilized for both active and passive targeting of the lymphatic system are discussed here. Specifically, due to the rich abundance of lymphatic capillaries in the dermis, particular attention is given to this route of administration, as intradermal administration could potentially result in higher lymphatic uptake compared to other routes of administration. Recently, progress in microneedle research has attracted particular attention as an alternative for the use of conventional hypodermic injections. The benefits of microneedles, when compared to intradermal injection, are subsequently highlighted. Importantly, microneedles exhibit particular benefit in relation to therapeutic targeting of the lymphatic system, especially when combined with nanoparticles, which are further discussed. However, despite the apparent benefits provided by this combination approach, further comprehensive preclinical and clinical studies are now necessary to realize the potential extent of this dual-delivery platform, further taking into consideration eventual usability and acceptability in the intended patient end-users. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology.
许多疾病已被报道会影响淋巴系统。因此，已经开发了几种策略来将化疗药物递送到这个特定的组织和相关器官的淋巴网络中。纳米技术已被用作提高药物淋巴摄取的主要方法之一。本文讨论了用于主动和被动靶向淋巴系统的不同纳米颗粒方法。具体而言，由于真皮中富含丰富的淋巴毛细血管，因此特别关注这种给药途径，因为与其他给药途径相比，皮内给药可能导致更高的淋巴摄取。最近，微针研究的进展引起了人们的特别关注，它是替代传统皮下注射的一种方法。随后强调了微针相对于皮内注射的优势。重要的是，微针在淋巴系统的治疗靶向方面具有特别的优势，特别是与纳米颗粒结合使用时，本文将进一步讨论这一点。然而，尽管这种联合方法具有明显的优势，但现在仍需要进行更全面的临床前和临床研究，以实现这一双重递药平台的潜在程度，同时进一步考虑最终在预期的患者终端用户中的可用性和可接受性。本文属于以下类别： 治疗方法和药物发现 > 新兴技术 纳米技术在生物学中的应用 > 生物学中的纳米级系统。
