State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; NHC Key Laboratory of Comparative Medicine, National Center of Technology Innovation for Animal Model, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College, Beijing 100021, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China; Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Adv Drug Deliv Rev. 2024 Jun;209:115304. doi: 10.1016/j.addr.2024.115304. Epub 2024 Apr 9.
The lymphatic system has garnered significant attention in drug delivery research due to the advantages it offers, such as enhancing systemic exposure and enabling lymph node targeting for nanomedicines via the lymphatic delivery route. The journey of drug carriers involves transport from the administration site to the lymphatic vessels, traversing the lymph before entering the bloodstream or targeting specific lymph nodes. However, the anatomical and physiological barriers of the lymphatic system play a pivotal role in influencing the behavior and efficiency of carriers. To expedite research and subsequent clinical translation, this review begins by introducing the composition and classification of the lymphatic system. Subsequently, we explore the routes and mechanisms through which nanoparticles enter lymphatic vessels and lymph nodes. The review further delves into the interactions between nanomedicine and body fluids at the administration site or within lymphatic vessels. Finally, we provide a comprehensive overview of recent advancements in lymphatic delivery systems, addressing the challenges and opportunities inherent in current systems for delivering macromolecules and vaccines.
淋巴系统在药物递送研究中受到了极大的关注，因为它具有许多优势，例如通过淋巴递药途径提高全身暴露度并实现纳米药物对淋巴结的靶向作用。药物载体的输送过程涉及从给药部位到淋巴管的运输，在进入血液或靶向特定淋巴结之前，药物载体需要穿过淋巴。然而，淋巴系统的解剖学和生理学屏障在影响载体的行为和效率方面起着关键作用。为了加速研究和后续的临床转化，本综述首先介绍了淋巴系统的组成和分类。随后，我们探讨了纳米颗粒进入淋巴管和淋巴结的途径和机制。本综述还深入研究了纳米药物在给药部位或淋巴管内与体液的相互作用。最后，我们全面概述了淋巴递药系统的最新进展，探讨了当前用于递送大分子和疫苗的系统所固有的挑战和机遇。
