Gorini Francesca, Del Turco Serena, Sabatino Laura, Gaggini Melania, Vassalle Cristina
Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.
Fondazione CNR-Regione Toscana G. Monasterio, 56124 Pisa, Italy.
Biomedicines. 2021 Aug 28;9(9):1107. doi: 10.3390/biomedicines9091107.
The endothelium controls vascular homeostasis through a delicate balance between secretion of vasodilators and vasoconstrictors. The loss of physiological homeostasis leads to endothelial dysfunction, for which inflammatory events represent critical determinants. In this context, therapeutic approaches targeting inflammation-related vascular injury may help for the treatment of cardiovascular disease and a multitude of other conditions related to endothelium dysfunction, including COVID-19. In recent years, within the complexity of the inflammatory scenario related to loss of vessel integrity, hydrogen sulfide (HS) has aroused great interest due to its importance in different signaling pathways at the endothelial level. In this review, we discuss the effects of HS, a molecule which has been reported to demonstrate anti-inflammatory activity, in addition to many other biological functions related to endothelium and sulfur-drugs as new possible therapeutic options in diseases involving vascular pathobiology, such as in SARS-CoV-2 infection.
内皮细胞通过血管舒张剂和血管收缩剂分泌之间的微妙平衡来控制血管稳态。生理稳态的丧失会导致内皮功能障碍，而炎症事件是其关键决定因素。在这种情况下，针对炎症相关血管损伤的治疗方法可能有助于治疗心血管疾病以及许多其他与内皮功能障碍相关的病症，包括新冠肺炎。近年来，在与血管完整性丧失相关的复杂炎症情况中，硫化氢（HS）因其在内皮水平不同信号通路中的重要性而引起了极大关注。在这篇综述中，我们讨论了HS的作用，除了许多其他与内皮相关的生物学功能外，HS还具有抗炎活性，并且我们还探讨了含硫药物作为涉及血管病理生物学疾病（如SARS-CoV-2感染）新的可能治疗选择的情况。
