College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
College of Foreign Languages, Shandong University of Traditional Chinese Medicine, Jinan, China.
J Drug Target. 2021 Aug;29(7):677-686. doi: 10.1080/1061186X.2020.1870987. Epub 2021 Jan 12.
Previous studies have found that oxidative stress is the negative reaction of the imbalance between oxidation and antioxidation caused by free radicals, and it is the fuse of aging and many diseases. Scavenging the accumulation of free radicals in the body and inhibiting the production of free radicals are effective ways to reduce the occurrence of oxidative stress. In recent years, studies have found that oxidative stress has other effects on the body, such as anti-tumour. In this paper, the targets related to anti-oxidative stress were introduced, and they were divided into nuclear transcription factors, enzymes, solute carrier family 7, member 11 (SLC7A11) genes and iron death, ion channels, molecular chaperones, small molecules according to their different functions. In addition, we introduce the research status of agonists/inhibitors related to these targets, so as to provide some reference for the follow-up research and clinical application of anti-oxidative stress drugs.
先前的研究发现，氧化应激是由自由基引起的氧化与抗氧化失衡的负向反应，是衰老和许多疾病的导火索。清除体内自由基的积累并抑制自由基的产生是减少氧化应激发生的有效方法。近年来，研究发现氧化应激对机体还有其他作用，如抗肿瘤。本文介绍了与抗氧化应激相关的靶点，根据其不同的功能将其分为核转录因子、酶、溶质载体家族 7 成员 11（SLC7A11）基因和铁死亡、离子通道、分子伴侣、小分子等。此外，还介绍了这些靶点相关激动剂/抑制剂的研究现状，以期为抗氧化应激药物的后续研究和临床应用提供一定的参考。
