Zivkovic Andjela, Jotic Ana, Dozic Ivan, Randjelovic Simona, Cirkovic Ivana, Medic Branislava, Milovanovic Jovica, Trivić Aleksandar, Korugic Aleksa, Vukasinović Ivan, Savic Vujovic Katarina
Faculty of Medicine, University of Belgrade, Dr Subotica 1, P.O. Box 38, 11129 Belgrade, Serbia.
Clinic for Otorhinolaryngology and Maxillofacial Surgery, University Clinical Center, Serbia Pasterova 2, 11129 Belgrade, Serbia.
Cells. 2024 Nov 23;13(23):1951. doi: 10.3390/cells13231951.
(1) Background: Laryngeal surgery due to carcinoma leads to significant tissue disruption, cellular injury, and inflammation. This leads to increased levels of reactive oxygen species (ROS), causing oxidative damage that can influence quality of life (QOL) and recovery and complicate the postoperative course. The aim of this study was to compare how postoperative quality of life and surgical complication occurrence interacted with the biomarker levels of oxidative stress (malondialdehyde, MDA; superoxide dismutase, SOD; glutathione peroxidase 1, GPX1; and catalase, CAT) and inflammation (interleukin 1, IL-1; interleukin 6, IL-6; C-reactive protein, CRP) in patients treated with conservative and radical laryngeal surgery. (2) Methods: The study included 56 patients who underwent surgical treatment for laryngeal cancer. Blood samples were collected to analyze oxidative stress and inflammation parameters before surgery and on the first and seventh days postoperatively. Serum concentrations of MDA, SOD, GPX, CAT, IL-1, IL-6, and CRP were measured using coated enzyme-linked immunosorbent assay (ELISA) kits. EORTC QLQ-H&H43 questionnaire was used to measure the QOL of patients. (3) Results and Conclusions: T stage, pain intensity, and the extent of the surgical procedure were established as significant predictive factors for QOL in multivariate analysis. There was a significant positive correlation between surgical complication occurrence and preoperative values of GPX and MDA, but significant predictors of surgical complication occurrence on the 7th postoperative day were SOD and MDA values ( < 0.05).
(1) 背景：因癌症进行的喉部手术会导致显著的组织破坏、细胞损伤和炎症。这会导致活性氧（ROS）水平升高，引发氧化损伤，进而影响生活质量（QOL）和恢复情况，并使术后病程复杂化。本研究的目的是比较在接受保守性和根治性喉部手术的患者中，术后生活质量和手术并发症的发生与氧化应激生物标志物水平（丙二醛，MDA；超氧化物歧化酶，SOD；谷胱甘肽过氧化物酶1，GPX1；过氧化氢酶，CAT）以及炎症生物标志物水平（白细胞介素1，IL-1；白细胞介素6，IL-6；C反应蛋白，CRP）之间的相互作用。(2) 方法：该研究纳入了56例接受喉癌手术治疗的患者。在手术前、术后第1天和第7天采集血样，以分析氧化应激和炎症参数。使用包被酶联免疫吸附测定（ELISA）试剂盒测量MDA、SOD、GPX、CAT、IL-1、IL-6和CRP的血清浓度。采用欧洲癌症研究与治疗组织QLQ-H&H43问卷来测量患者的生活质量。(3) 结果与结论：在多因素分析中，T分期、疼痛强度和手术范围被确定为生活质量的显著预测因素。手术并发症的发生与术前GPX和MDA值之间存在显著正相关，但术后第7天手术并发症发生情况的显著预测因素是SOD和MDA值（<0.05）。
