Department of Ocean Science and Hong Kong Branch of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Hong Kong University of Science and Technology, Hong Kong, China.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Biofouling. 2020 Nov;36(10):1210-1226. doi: 10.1080/08927014.2020.1864343. Epub 2021 Jan 5.
In the present review, 182 antifouling (AF) natural products from marine microorganisms, algae and marine invertebrates reported from August 2014 to May 2020 are presented. Amongst these compounds, over half were isolated from marine-derived microorganisms, including 70 compounds from fungi and 31 compounds from bacteria. The structure-relationship of some of these compounds is also briefly discussed. Based on the work reported, a general workflow was drafted to refine the procedures for the commercialization of any novel AF compounds. Finally, butenolide, which is considered a potential environmentally friendly antifoulant, is used as a case study to show the procedures involved in AF compound work from the aspect of discovery, structure optimization, toxicity, stability, AF mechanism and coating incorporation, which highlight the current challenges and future perspectives in AF compound research.
在本次综述中，呈现了自 2014 年 8 月至 2020 年 5 月期间从海洋微生物、藻类和海洋无脊椎动物中分离得到的 182 种具有抗污（AF）活性的天然产物。这些化合物中，超过一半是从海洋来源的微生物中分离得到的，其中包括 70 种真菌来源的化合物和 31 种细菌来源的化合物。本文还简要讨论了其中一些化合物的结构-活性关系。根据已报道的工作，制定了一个通用的工作流程，以改进任何新型 AF 化合物的商业化程序。最后，以丁烯内酯为例，探讨了作为一种潜在的环保型防污剂的应用前景，从发现、结构优化、毒性、稳定性、AF 机制和涂层结合等方面展示了 AF 化合物研究的工作流程，强调了 AF 化合物研究中当前面临的挑战和未来展望。
Zotero 插件