College of Chemistry and Chemical Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Mar Drugs. 2024 May 7;22(5):213. doi: 10.3390/md22050213.
Marine sponges of the genus have proven to be unabated sources of novel secondary metabolites with remarkable scaffold diversities and significant bioactivities. The discovery of chemical substances from sponges has continued to increase over the last few years. The current work provides an up-to-date literature survey and comprehensive insight into the reported metabolites from the members of the genus , as well as their structural features, biological activities, and structure-activity relationships when available. In this review, 222 metabolites are discussed based on published data from the period from mid-2015 to the beginning of 2024. The compounds are categorized into sesquiterpenes, diterpenes, sesterterpenes, meroterpenes, linear furanoterpenes, steroids, alkaloids, and other miscellaneous substances. The biological effects of these chemical compositions on a vast array of pharmacological assays including cytotoxic, anti-inflammatory, antibacterial, neuroprotective, protein tyrosine phosphatase 1B (PTP1B)-inhibitory, and phytoregulating activities are also presented.
已证明属于 的海洋海绵是新型次生代谢产物的不竭来源，具有显著的支架多样性和重要的生物活性。近年来，人们不断发现海绵中的化学物质。目前的工作提供了最新的文献综述，全面深入地了解了该属成员的报道代谢产物，以及它们的结构特征、生物活性，以及在有条件的情况下的结构-活性关系。在这篇综述中，根据 2015 年年中至 2024 年初期间发表的数据，讨论了 222 种代谢产物。这些化合物分为倍半萜、二萜、甾体、混合萜、线性呋喃萜、甾体、生物碱和其他杂项物质。这些化学成分对广泛的药理学测定的生物效应，包括细胞毒性、抗炎、抗菌、神经保护、蛋白酪氨酸磷酸酶 1B（PTP1B）抑制和植物调节活性也进行了介绍。
