胆固醇：生物活性、结构修饰、作用机制和构效关系。

Cholesterol: Bioactivities, Structural Modification, Mechanisms of Action, and Structure-Activity Relationships.

机构信息

College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi Province, China.

Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, Zhejiang Province, China.

出版信息

Mini Rev Med Chem. 2021;21(14):1830-1848. doi: 10.2174/1389557521666210105123320.

DOI:10.2174/1389557521666210105123320

PMID:33402086

Abstract

Cholesterol, steroid alcohol, was discovered by M.E. Chevreul in 1815. Cholesterol and its derivatives showed a large variety of biological properties such as anticancer activity, anticardiac activity, anti-inflammatory activity, antimicrobial activity, anti-psychotic activity, antioxidant activity, drug-loaded activity, etc. In this mini-review, the advances of structural modification of cholesterol from 2014 to 2020 are summarized. In addition, the bioactivities, mechanisms of action and structureactivity relationships of cholesterol and its related derivatives are also discussed.

摘要

胆固醇，甾体醇，于 1815 年由 M.E. 谢弗勒尔发现。胆固醇及其衍生物表现出多种生物学特性，如抗癌活性、抗心脏活性、抗炎活性、抗菌活性、抗精神病活性、抗氧化活性、载药活性等。在这个小型综述中，总结了 2014 年至 2020 年胆固醇结构修饰的进展。此外，还讨论了胆固醇及其相关衍生物的生物活性、作用机制和构效关系。