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本文引用的文献

1
Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin.呼出气中颗粒和表面活性蛋白 A 及白蛋白含量的个体内变异。
PLoS One. 2020 Jan 24;15(1):e0227980. doi: 10.1371/journal.pone.0227980. eCollection 2020.
2
Toward clinically applicable biomarkers for asthma: An EAACI position paper.迈向哮喘临床适用生物标志物：一项 EAACI 立场文件。
Allergy. 2019 Oct;74(10):1835-1851. doi: 10.1111/all.13806.
3
Determinants of fractional exhaled nitric oxide in healthy men and women from the European Community Respiratory Health Survey III.健康男性和女性呼出气一氧化氮分数的决定因素：来自欧洲社区呼吸健康调查 III。
Clin Exp Allergy. 2019 Jul;49(7):969-979. doi: 10.1111/cea.13394. Epub 2019 Apr 14.
4
Cellular analysis in bronchoalveolar lavage: inherent limitations of current standard procedure.支气管肺泡灌洗中的细胞分析：当前标准程序的固有局限性
Eur Respir J. 2017 Jun 1;49(6). doi: 10.1183/13993003.01844-2016. Print 2017 Jun.
5
A European Respiratory Society technical standard: exhaled biomarkers in lung disease.欧洲呼吸学会技术标准：肺部疾病的呼出气生物标志物。
Eur Respir J. 2017 Apr 26;49(4). doi: 10.1183/13993003.00965-2016. Print 2017 Apr.
6
Effect of cholesterol on the molecular structure and transitions in a clinical-grade lung surfactant extract.胆固醇对临床级肺表面活性剂提取物分子结构及转变的影响
Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3592-E3601. doi: 10.1073/pnas.1701239114. Epub 2017 Apr 17.
7
Exhaled Particles After a Standardized Breathing Maneuver.标准化呼吸动作后的呼出颗粒
J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):267-273. doi: 10.1089/jamp.2016.1330. Epub 2017 Mar 9.
8
Spirometric reference equations for Swedish adults.瑞典成年人的肺量计参考方程。
Clin Physiol Funct Imaging. 2017 Nov;37(6):640-645. doi: 10.1111/cpf.12349. Epub 2016 Feb 10.
9
Surfactant Lipids at the Host-Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease.宿主-环境界面的表面活性脂质。炎症性肺病的代谢传感器、抑制剂和效应器。
Am J Respir Cell Mol Biol. 2016 May;54(5):624-35. doi: 10.1165/rcmb.2016-0011PS.
10
Exhaled particles as markers of small airway inflammation in subjects with asthma.呼出颗粒作为哮喘患者小气道炎症的标志物。
Clin Physiol Funct Imaging. 2017 Sep;37(5):489-497. doi: 10.1111/cpf.12323. Epub 2015 Dec 9.

呼出气中新型无创性粒子检测方法探索小气道衬液：一项欧洲基于人群的队列研究。

Novel non-invasive particles in exhaled air method to explore the lining fluid of small airways-a European population-based cohort study.

机构信息

Public Health and Community Medicine, University of Gothenburg Sahlgrenska Academy, Goteborg, Sweden.

Department of Respiratory Medicine and Allergology, Insitute of Medicine, Gothenburg, Sweden.

出版信息

BMJ Open Respir Res. 2021 Jan;8(1). doi: 10.1136/bmjresp-2020-000804.

DOI:10.1136/bmjresp-2020-000804
PMID:33402401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7786806/
Abstract

INTRODUCTION

Respiratory tract lining fluid of small airways mainly consists of surfactant that can be investigated by collection of the particles of exhaled aerosol (PExA) method. This offers an exciting prospect to monitor small airway pathology, including subjects with asthma and smokers.

AIM

To explore the influence of anthropometric factors and gender on phospholipids, surfactant protein A (SP-A) and albumin of the lining fluid of small airwaysand to examine the association with asthma and smoking. Furthermore, to examine if the surfactant components can predict lung function in terms of spirometry variables.

METHOD

This study employs the population-based cohort of the European Community Respiratory Health Survey III, including participants from Gothenburg city, Sweden (n=200). The PExA method enabled quantitative description and analytical analysis of phospholipids, SP-A and albumin of the lining fluid of small airways.

RESULTS

Age was a significant predictor of the phospholipids. The components PC14:0/16:0, PC16:0/18:2 (PC, phosphatidylcholine) and SP-A were higher among subjects with asthma, whereas albumin was lower. Among smokers, there were higher levels particularly of di-palmitoyl-di-phosphatidyl-choline compared with non-smokers. Most phospholipids significantly predicted the spirometry variables.

CONCLUSION

This non-invasive PExA method appears to have great potential to explore the role of lipids and proteins of surfactant in respiratory disease.

摘要

简介

小气道的呼吸道衬液主要由表面活性剂组成，可以通过收集呼出气溶胶颗粒（PExA）的方法进行研究。这为监测小气道病理学提供了一个令人兴奋的前景，包括哮喘患者和吸烟者。

目的

探讨人体测量因素和性别对小气道衬液中磷脂、表面活性蛋白 A（SP-A）和白蛋白的影响，并研究其与哮喘和吸烟的关系。此外，还研究了表面活性剂成分是否可以通过肺功能的肺活量变量来预测。

方法

本研究采用了欧洲社区呼吸系统健康调查 III 的基于人群的队列，包括瑞典哥德堡市的参与者（n=200）。PExA 方法能够定量描述和分析小气道衬液中的磷脂、SP-A 和白蛋白。

结果

年龄是磷脂的一个显著预测因子。与非哮喘患者相比，哮喘患者的 PC14:0/16:0、PC16:0/18:2（PC，磷脂酰胆碱）和 SP-A 等成分更高，而白蛋白则更低。与非吸烟者相比，吸烟者中双棕榈酰-二磷酸酰胆碱等成分的水平更高。大多数磷脂与肺活量变量显著相关。

结论

这种非侵入性的 PExA 方法似乎具有很大的潜力，可以探索脂质和表面活性剂蛋白在呼吸疾病中的作用。