Department of Bromatology, Medical University of Warsaw, Warsaw, Poland.
Department of Bromatology, Medical University of Warsaw, Warsaw, Poland
In Vivo. 2021 Jan-Feb;35(1):259-266. doi: 10.21873/invivo.12254.
BACKGROUND/AIM: The aim of the study was to determine the effect of various diets with zinc or zinc in combination with resveratrol or genistein on mineral contents of the serum, urine, liver, kidney and heart in rats with chemically-induced mammary carcinoma.
The manuscript presents the tissues and body fluids content of iron, calcium, zinc, magnesium and copper in control rats or rats treated with 7,12-dimethyl-1,2-benz[a]anthracene to induce mammary carcinogenesis, under four dietary conditions: standard feed, Zn supplemented feed (6.9 mg Zn/ml), Zn and resveratrol (0.2 mg/kg body) supplemented feed, or Zn and genistein (0.2 mg/kg body) supplemented feed.
The content of calcium and copper highly varied depending on the tissue and the type of dietary supplement (no change for zinc and magnesium). Irrespective of the diet used, the chemical induction of mammary cancer caused a decrease in iron concentration in most samples analysed. Only supplementation of the rats' diet with zinc and genistein induced no changes in iron distribution in the serum, urine, liver, kidney and heart.
Further research using various levels of zinc and genistein in the diet should be conducted to determine how the development and progression of cancer is linked to iron content in cells and its ability to accumulate in tumour tissue.
背景/目的：本研究旨在确定不同含锌或锌与白藜芦醇或染料木黄酮组合的饮食对化学诱导的乳腺癌大鼠血清、尿液、肝脏、肾脏和心脏中矿物质含量的影响。
本文介绍了在四种饮食条件下（标准饲料、补充锌（6.9mg Zn/ml）的饲料、补充锌和白藜芦醇（0.2mg/kg 体重）的饲料、或补充锌和染料木黄酮（0.2mg/kg 体重）的饲料），对照组大鼠或用 7,12-二甲基-1,2-苯并[a]蒽诱导乳腺癌发生的大鼠的组织和体液中铁、钙、锌、镁和铜含量。
钙和铜的含量高度取决于组织和饮食补充剂的类型（锌和镁没有变化）。无论使用何种饮食，化学诱导的乳腺癌都会导致大多数分析样本中铁浓度降低。只有用锌和染料木黄酮补充大鼠饮食，才能在血清、尿液、肝脏、肾脏和心脏中不改变铁的分布。
应进行使用不同水平的锌和染料木黄酮饮食的进一步研究，以确定癌症的发展和进展与细胞内铁含量及其在肿瘤组织中积累的能力之间的关系。
