Department of Internal Medicine, Division of Gastroenterology and Hepatology, Hyogo College of Medicine, Nishinomiya, Japan;
Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan.
In Vivo. 2021 Jan-Feb;35(1):363-371. doi: 10.21873/invivo.12267.
BACKGROUND/AIM: To elucidate factors associated with secular changes of grip strength (GS) in patients with chronic liver diseases (CLDs) (n=241, 102 males, median age=63 years, 87 liver cirrhosis cases).
ΔGS (kg/year) was defined as [GS value (second time) - GS value (first time)]/[time interval between the first and second time]. GS loss (GSL) was defined as ΔGS <0 kg/year.
The median ΔGS in patients with non-LC, Child-Pugh A (n=70) and Child-Pugh B (n=17) were 0.3, -0.2 and -1.6 kg/year (overall p<0.0001). In the multivariate analysis of factors linked to the GSL for all cases, extracellular water (ECW) to total body water (TBW) ratio was significant (p=0.0007). In the multivariate analysis in male, no significant factor was found, while in female, ECW to TBW ratio was significant (p=0.0024).
Liver functional parameters can be closely linked to the GSL especially in female CLD patients.
背景/目的：阐明与慢性肝病（CLD）患者握力（GS）的长期变化相关的因素（n=241，男性 102 例，中位年龄 63 岁，87 例肝硬化）。
ΔGS（kg/年）定义为[第二次 GS 值-第一次 GS 值]/[第一次和第二次之间的时间间隔]。GS 损失（GSL）定义为 ΔGS <0 kg/年。
非 LC、Child-Pugh A（n=70）和 Child-Pugh B（n=17）患者的中位 ΔGS 分别为 0.3、-0.2 和-1.6 kg/年（总体 p<0.0001）。在所有病例与 GSL 相关的因素的多变量分析中，细胞外液（ECW）与总体水（TBW）的比值具有显著性（p=0.0007）。在男性的多变量分析中，未发现显著因素，而在女性中，ECW 与 TBW 的比值具有显著性（p=0.0024）。
肝功能参数与 GSL 密切相关，尤其是在女性 CLD 患者中。
